Elucidating the role of Streptomyces as probiotic in Vibrio parahaemolyticus-infected zebrafish as a model for sustainable aquafarming

In aquafarming, the increasing menace of Vibrio parahaemolyticus infections emerges as a formidable impediment to global seafood production. Increased animal stocking, overcrowding, and lack of sanitary management cause the rapid Vibrio parahaemolyticus infection in aquafarming. The conventional treatment approaches, predominantly reliant on antibiotics, not only fall short of providing effective solutions but also pose imminent environmental threats. The emergence of multidrug-resistant pathogens in the environment is of public concern and a challenge for clinical treatments. Recognizing this urgent challenge, our project seeks to present an innovative and sustainable alternative by delving into the potential of Streptomyces sp. as probiotics. Vibrio parahaemolyticus infections not only compromise the health of aquatic organisms but also ripple through entire ecosystems, impacting economic and ecological sustainability. By strategically leveraging zebrafish as a model, our research aims to elucidate the efficacy of Streptomyces probiotics in combating these infections. This project intends to study the effectiveness of Streptomyces sp. L01 as the potential probiotic treatment to combat the infectious agent Vibrio parahaemolyticus. The protective role of Streptomyces as a probiotic in the zebrafish gut will be analyzed via in-vitro trials. Following that, the zebrafish will be infected with the Vibrio parahaemolyticus KVP39 and treated with the probiotics in the in-vivo studies. By leveraging the zebra-Vibrio model to assess the efficacy of probiotics, this project represents a crucial step toward sustainable aquafarming practices. The outcomes have the potential to transform aquaculture strategies, safeguard aquatic ecosystems, maintain production, and reduce the dependency on antibiotics.