Elucidating the post-transcriptional regulation of mast cell proteases

  • Hertzog, Paul (Primary Chief Investigator (PCI))
  • Hansbro, Philip (Chief Investigator (CI))
  • Stevens, Richard (Partner Investigator (PI))

Project: Research

Project Description

Mast cells (MCs) are immune cells that protect against pathogens but induce deleterious inflammation. MC
function is mediated by specific proteases that are pre-formed and stored in granules. These proteases have
unique yet poorly understood mechanisms of regulation. We will use a novel suite of molecular tools and
genetically modified mice and to identify the critical regions of transcripts that post-transcriptionally regulate
the production and storage of these proteins. We will then identify the RNA binding proteins, microRNAs and
other novel factors that also regulate them. This will elucidate the post-transcriptional mechanisms of
regulation of MC proteases.
StatusFinished
Effective start/end date1/01/1531/12/17

Funding

  • Australian Research Council (ARC)