This funding request will provide support for the continued development and implementation of a novel, self-sustaining and cost-effective Wolbachia control method to prevent transmission of a range of arboviral diseases including those caused by dengue, chikungunya and Zika viruses. The World Mosquito Program (WMP/Program), formerly called the Eliminate Dengue Program, has an ambitious and achievable plan to scale-up its deployments on the assumption that accumulating efficacy evidence shows significant disease impact.