Electrophile Induced Domino Reaction Sequences with Ion-Pair Chiral Induction

Organic synthesis is often the linchpin in the transition of knowledge to technology in areas such as drugdiscovery
and materials science. However, the efficiency and flexibility with which organic molecules can be
prepared and manipulated diminishes rapidly with increasing structural complexity. Molecules containing
multiple stereocentres and/or highly condensed polycyclic arrangements are particularly challenging to
prepare in meaningful quantities. Addressing this challenge requires the emergence of new synthetic
methods that can install multiple bonds stereoselectively and in high efficiency. In this project, new catalysts
and procedures will be developed to address these requirements.