Effect of miR-153 overexpression on the inflammation-induced depression-like phenotype

Project: Research

Project Details

Project Description

Depression is a multifactorial disorder, and it is one of the significant risk factors for suicide deaths that accounts for about 800000 per year globally. Further, depression impairs the socio-economic ability of the affected individual and increases the risk for other morbidity and mortality, thus leading to the global burden of the disease. According to the world health organization (WHO), about 322 million global populations, equivalent to 4.4%, are affected by depression. The highest estimated prevalence is in Southeast Asia, with 27% million of the world population in 2015. The prevalence increases in low-income countries primarily due to socio-economic stress factors.
Depression is affected by many aspects, including genetic factors influencing candidate genes that moderate the neurobiological system and gene variants or structures that increase susceptibility to depression. In the last decade, neuro-inflammation also has been implicated in depression pathophysiology affecting the immune system. Dysregulated inflammatory system are persistently reported in depressed patients and affect the prognosis, particularly the anti-depressant responses (3). Anti-inflammatory as a co-adjuvant in treating depressed patients with increased inflammation reported to exhibit responsiveness towards the treatment. However, anti-inflammation consumption for a prolonged period may comprise immunity. Therefore, a therapeutic intervention that can modify inflammation without compromising immunity holds an overall benefit.
Recently, microRNAs (miRNAs/ miR) have been reported to play an essential role in many diseases’ pathology. There are several miRNAs found to play essential role in the neuroinflammation in the central nervous system. MiR-153 attenuated inflammatory responses in several studies, and plays a critical role in many pathological diseases. However, the role of miR-153 in depression is unknown. Therefore, this study aims to explore further the functional role of overexpression miR-153 in depression pathogenesis induced by inflammation.
StatusFinished
Effective start/end date1/09/22 → 1/03/24

Keywords

  • miR-153
  • Habenula
  • Inflammation
  • Depression