Dual Targeting of the Androgen Receptor for Effective and Durable Control of Lethal Prostate Cancer

Tilley, Wayne D. (Primary Chief Investigator (PCI))
Risbridger, Gail (Chief Investigator (CI))
Raj, Ganesh V (Chief Investigator (CI))
Selth, Luke A. (Chief Investigator (CI))
Taylor, Renea (Chief Investigator (CI))
Joshua, Anthony M (Chief Investigator (CI))

Project: Research

Project Description

Preventing binding of androgens to the androgen receptor is the mainstay treatment for advanced prostate cancer, but resistance inevitably develops and the disease becomes lethal. We will develop a new drug that targets a part of the androgen receptor unrelated to its androgen binding function to overcome resistance to current therapy. As this drug will be effective in all stages of prostate cancer, it has high potential to improve survival outcomes for men with prostate cancer.

Status	Finished
Effective start/end date	1/01/17 → 31/12/20

Funding

National Health and Medical Research Council (NHMRC) (Australia): A$1,095,560.00

5 Article

Androgen receptor enhancer amplification in matched patient-derived xenografts of primary and castrate-resistant prostate cancer
Porter, L. H., Bakshi, A., Pook, D., Clark, A., Clouston, D., Kourambas, J., MURAL investigators, Goode, D. L., Risbridger, G. P., Taylor, R. A. & Lawrence, M. G., Jun 2021, In: Journal of Pathology. 254, 2, p. 121-134 14 p.
Research output: Contribution to journal › Article › Research › peer-review

15 Citations (Scopus)
Post-transcriptional Gene Regulation by MicroRNA-194 Promotes Neuroendocrine Transdifferentiation in Prostate Cancer
Fernandes, R. C., Toubia, J., Townley, S., Hanson, A. R., Dredge, B. K., Pillman, K. A., Bert, A. G., Winter, J. M., Iggo, R., Das, R., Obinata, D., MURAL investigators, Sandhu, S., Risbridger, G. P., Taylor, R. A., Lawrence, M. G., Butler, L. M., Zoubeidi, A., Gregory, P. A., Tilley, W. D., & 3 othersHickey, T. E., Goodall, G. J. & Selth, L. A., 5 Jan 2021, In: Cell Reports. 34, 1, 23 p., 108585.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

30 Citations (Scopus)
The MURAL collection of prostate cancer patient-derived xenografts enables discovery through preclinical models of uro-oncology
Risbridger, G. P., Clark, A. K., Porter, L. H., Toivanen, R., Bakshi, A., Lister, N. L., Pook, D., Pezaro, C. J., Sandhu, S., Keerthikumar, S., Quezada Urban, R., Papargiris, M., Kraska, J., Madsen, H. B., Wang, H., Richards, M. G., Niranjan, B., O’Dea, S., Teng, L., Wheelahan, W., & 25 othersLi, Z., Choo, N., Ouyang, J. F., Thorne, H., Devereux, L., Hicks, R. J., Sengupta, S., Harewood, L., Iddawala, M., Azad, A. A., Goad, J., Grummet, J., Kourambas, J., Kwan, E. M., Moon, D., Murphy, D. G., Pedersen, J., Clouston, D., Norden, S., Ryan, A., Furic, L., Goode, D. L., Frydenberg, M., Lawrence, M. G. & Taylor, R. A., 19 Aug 2021, In: Nature Communications. 12, 1, 5049.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

40 Citations (Scopus)

Animal Research Platform (MARP)
Christine Findlay (Manager)
Faculty of Medicine Nursing and Health Sciences Research Platforms
Facility/equipment: Facility

Dual Targeting of the Androgen Receptor for Effective and Durable Control of Lethal Prostate Cancer

Project Details

Project Description

Funding

Research output

Androgen receptor enhancer amplification in matched patient-derived xenografts of primary and castrate-resistant prostate cancer

Post-transcriptional Gene Regulation by MicroRNA-194 Promotes Neuroendocrine Transdifferentiation in Prostate Cancer

The MURAL collection of prostate cancer patient-derived xenografts enables discovery through preclinical models of uro-oncology

Equipment

Animal Research Platform (MARP)