Drivers of effective T cell immunity

This proposal aims to investigate the mechanisms underpinning an effective immune response, a key unanswered question in the Life Sciences. It aims to decipher the various determinants of T cell immunity and explore how these determinants are integrated to generate effective immunity. To do this, the project will use an innovative, multidisciplinary approach to investigate antigen abundance and developmental, structural, and molecular aspects of T cells. In doing so, this project expects to significantly enhance our fundamental understanding of mechanisms underpinning functional T cell responses, build interdisciplinary collaborations, and significantly advance the field of T cell biology.