Discovering new drugs for epilepsy using personalised medicine

Kwan, Patrick (Primary Chief Investigator (PCI))
Rollo, Ben (Chief Investigator (CI))
Langmead, Christopher (Chief Investigator (CI))
Ayers, Katie L. (Chief Investigator (CI))
Harris, Alex (Chief Investigator (CI))

Project: Research

Status	Finished
Effective start/end date	1/06/20 → 31/05/22

Keywords

neuroscience
stem cell biology
disease modelling
drug discovery
epilepsy

3 Review Article
1 Article

The role of the adenosine system in epilepsy and its comorbidities
Baltos, J. A., Casillas-Espinosa, P. M., Rollo, B., Gregory, K. J., White, P. J., Christopoulos, A., Kwan, P., O'Brien, T. J. & May, L. T., 2023, (Accepted/In press) In: British Journal of Pharmacology. 15 p.
Research output: Contribution to journal › Review Article › Research › peer-review

Open Access
Variants in SART3 cause a spliceosomopathy characterised by failure of testis development and neuronal defects
Ayers, K. L., Eggers, S., Rollo, B. N., Smith, K. R., Davidson, N. M., Siddall, N. A., Zhao, L., Bowles, J., Weiss, K., Zanni, G., Burglen, L., Ben-Shachar, S., Rosensaft, J., Raas-Rothschild, A., Jørgensen, A., Schittenhelm, R. B., Huang, C., Robevska, G., van den Bergen, J., Casagranda, F., & 23 othersCyza, J., Pachernegg, S., Wright, D. K., Bahlo, M., Oshlack, A., O'Brien, T. J., Kwan, P., Koopman, P., Hime, G. R., Girard, N., Hoffmann, C., Shilon, Y., Zung, A., Bertini, E., Milh, M., Ben Rhouma, B., Belguith, N., Bashamboo, A., McElreavey, K., Banne, E., Weintrob, N., BenZeev, B. & Sinclair, A. H., 9 Jun 2023, In: Nature Communications. 14, 1, 21 p., 3403.
Research output: Contribution to journal › Article › Research › peer-review

Open Access
CDKL5 deficiency disorder: molecular insights and mechanisms of pathogenicity to fast-track therapeutic development
Van Bergen, N. J., Massey, S., Quigley, A., Rollo, B., Harris, A. R., Kapsa, R. M. I. & Christodoulou, J., 31 Aug 2022, In: Biochemical Society Transactions. 50, 4, p. 1207-1224 18 p.
Research output: Contribution to journal › Review Article › Research › peer-review

Open Access

2 Citations (Scopus)

FlowCore
Andrew Fryga (Manager)
Faculty of Medicine Nursing and Health Sciences Research Platforms
Facility/equipment: Facility
Histology Platform
Camilla Cohen (Manager)
Faculty of Medicine Nursing and Health Sciences Research Platforms
Facility/equipment: Facility
Monash Micro Imaging
Stephen Firth (Manager), Alex Fulcher (Operator), Oleks Chernyavskiy (Operator), Margaret Rzeszutek (Other), David Potter (Manager), Volker Hilsenstein (Operator), Juan Nunez-Iglesias (Other), Stephen Cody (Manager), Irena Carmichael (Operator), Betty Kouskousis (Other), Sarah Creed (Manager) & Giulia Ballerin (Operator)
Faculty of Medicine Nursing and Health Sciences Research Platforms
Facility/equipment: Facility

Discovering new drugs for epilepsy using personalised medicine

Project Details

Keywords

Research output

The role of the adenosine system in epilepsy and its comorbidities

Variants in SART3 cause a spliceosomopathy characterised by failure of testis development and neuronal defects

CDKL5 deficiency disorder: molecular insights and mechanisms of pathogenicity to fast-track therapeutic development

Equipment

FlowCore

Histology Platform

Monash Micro Imaging