This proposal investigates how a family of genes influence cells in the testis to become mature sperm. There are key aspects of this process that are highly conserved through evolution of animal species. The project aims to utilize a combination of genetic, cell biological and biochemical studies in both Drosophila and mice to compare the roles of different Snail family proteins in spermatogenesis. The proposed outcomes will define the different roles of highly similar proteins from the same family in differentiation of a single cell lineage. This is a fundamental question to answer in the quest to generate functional tissues using in vitro laboratory approaches or to comprehend how normal development and developmental disorders arise.
|Effective start/end date||11/01/17 → 10/01/20|