Diet influences the selective advantage of mitochondrial DNA mutations

  • Ballard, John William Oman (Primary Chief Investigator (PCI))
  • St John, Justin (Chief Investigator (CI))
  • Smyth, Gordon K (Chief Investigator (CI))

    Project: Research

    Project Details

    Project Description

    The aim of the proposal is to test the hypothesis that mitochondrial DNA haplotypes have the potential to be under
    nutritionally induced balancing selection as a consequence of cellular signalling and/or ATP production by
    mitochondria. The project is significant because diet can vary both seasonally and geographically and is a key
    environmental parameter that influences the ability of a species to colonise new habitats. Innovatively, it will
    characterize the functional links between specific mitochondrial DNA haplotypes, mitochondrial functions and
    organismal traits. The outcome will be a more precise grasp of the processes influencing genetic variation within
    and among species, which will inform current issues in ecology and genetics.
    Effective start/end date1/01/1631/12/19