Development of non-iodinated, non ionic, water-soluble metal based compounds for clinical administration as radiographic contrast media.

  • Junk, Peter (Primary Chief Investigator (PCI))
  • Andrews, Philip (Chief Investigator (CI))
  • Midgley, Stewart Michael (Chief Investigator (CI))
  • Silberstein, Morry (Chief Investigator (CI))

Project: Research

Project Details

Project Description

Almost one million CT scans are performed on patients in Australia every year, growing at an annual rate of 5%. To allow visualisation of pathological problems large volumes of iodine based contrast imaging agents are injected into the patient. Unfortunately, 1% of the population is allergic to these (with moderate and sometimes severe cardiovascular, anaphylactic and pain reactions) and 1 in 20,000 people die after intravenous administration. This proposal will develop new non-toxic contrast agents based on stable bismuth and rare earth metal oxide/hydroxide cluster molecules, leading to greater patient comfort and safety, and improved diagnoses through significantly enhanced contrast.
StatusFinished
Effective start/end date1/04/0531/07/08

Funding

  • Australian Research Council (ARC): AUD300,000.00
  • Monash University
  • Monash University