Research output per year
Research output per year
Project Details
Project Description
A cardinal feature of adaptive immune cell activation is the initiation of a program of differentiation that results in acquisition and long term maintenance of lineage-specific effector function. Using a multidisciplinary approach including cellular and chromatin biology, advanced bioinformatics,targeted genome editing and nanotechnology, this proposal aims to identify the molecular mechanisms that regulate the activity of transcriptional enhancers needed for directing effective immune cell differentiation. This proposal will provide insights into the key mechanisms of non-coding regulatory element reprogramming and control of immune cell function and memory that will have implications for understanding general cellular differentiation.
| Status | Finished |
|---|---|
| Effective start/end date | 1/01/17 → 31/12/20 |
Funding
- Australian Research Council (ARC): A$461,500.00
- Monash University – Internal Faculty Contribution: A$134,053.00
- University of Canberra: A$119,556.00
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Active maintenance of CD8+ T cell naivety through regulation of global genome architecture
Russ, B. E., Barugahare, A., Dakle, P., Tsyganov, K., Quon, S., Yu, B., Li, J., Lee, J. K. C., Olshansky, M., He, Z., Harrison, P. F., See, M., Nussing, S., Morey, A. E., Udupa, V. A., Bennett, T. J., Kallies, A., Murre, C., Collas, P., Powell, D., & 2 others, 31 Oct 2023, In: Cell Reports. 42, 10, 19 p., 113301.Research output: Contribution to journal › Article › Research › peer-review
Open Access4 Citations (Scopus) -
DNA architectural protein CTCF facilitates subset-specific chromatin interactions to limit the formation of memory CD8+ T cells
Quon, S., Yu, B., Russ, B. E., Tsyganov, K., Nguyen, H., Toma, C., Heeg, M., Hocker, J. D., Milner, J. J., Crotty, S., Pipkin, M. E., Turner, S. J. & Goldrath, A. W., 9 May 2023, In: Immunity. 56, 5, p. 959-978.e10 31 p.Research output: Contribution to journal › Article › Research › peer-review
9 Citations (Scopus) -
SATB1 ensures appropriate transcriptional programs within naïve CD8+ T cells
Nüssing, S., Miosge, L. A., Lee, K., Olshansky, M., Barugahare, A., Roots, C. M., Sontani, Y., Day, E. B., Koutsakos, M., Kedzierska, K., Goodnow, C. C., Russ, B. E., Daley, S. R. & Turner, S. J., Sept 2022, In: Immunology and Cell Biology. 100, 8, p. 636-652 17 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access4 Citations (Scopus)