A cardinal feature of adaptive immune cell activation is the initiation of a program of differentiation that results in acquisition and long term maintenance of lineage-specific effector function. Using a multidisciplinary approach including cellular and chromatin biology, advanced bioinformatics,targeted genome editing and nanotechnology, this proposal aims to identify the molecular mechanisms that regulate the activity of transcriptional enhancers needed for directing effective immune cell differentiation. This proposal will provide insights into the key mechanisms of non-coding regulatory element reprogramming and control of immune cell function and memory that will have implications for understanding general cellular differentiation.
|Effective start/end date||1/01/17 → 31/12/19|
- Australian Research Council (ARC): AUD461,500.00
- Monash University – Internal Faculty Contribution: AUD134,053.00
- University of Canberra: AUD119,556.00