Our goal is to detect infrared-biomarkers for canine cancer. Dog cancers make excellent models for human cancers because of their similarity in type and location and in some cases, cancer treatments initially developed for dogs have been carried over to human medicine. We will investigate canine cancer using infrared light starting with DNA, then moving to the single cell and finally tissues. We will develop new methods that incorporate state-of-the-art infrared imaging technology along with artificial intelligent systems to diagnose cancer and monitor treatments. We expect to find specific infrared biomarkers for a number of dog cancers that will lead to improved diagnostics and ultimately benefit clinical outcomes and cancer research.