Designing Nanoparticles to Combat Cellular Dysfunction

This proposal involves the design, synthesis and characterization of nanoparticles capable of mediating the adverse affects of reactive oxygen species. The successful completion of the project will see the development of nanoparticles with tailored chemical functionality for modulating the concentration of reactive oxygen species and develop a potential new platform technology for addressing conditions where such reactive species are
overproduced. The project will elucidate the complex rules on how the physicochemical properties of the nanoparticles affect their activity, and examine the ability of the particles to affect cellular function, tissue morphology and particle transport in a biological milieu.