Designing effective Gram negative bacterial vaccines

Bacterial infections have a huge impact on human and animal health in Australia. These infections typically
cost the sheep industry 23 million dollars annually and were responsible for more than 120,000 notifications
of human disease last year. There is thus an urgent need to develop novel vaccines against these diseases.
The current proposal will address this need through the development of nano-sized bacterial vesicles as selfadjuvanted
vaccines. We will determine the immunogenic properties of bacterial vesicles and how these
properties can be harnessed to develop new vaccines. Expanding our understanding of these nanoparticles
will result in the generation of novel vaccines against bacterial infections in animals and humans.