The primary aim of this application is to enhance the thermodynamic and folding properties of proteins by
redesign and engineering. The structures and folding behaviour of the redesigned proteins will be
characterised using X-ray crystallography and biophysical techniques. This will produce two major outcomes:
(1) new proteins that can be used in biotechnology, medical and pharmaceutical applications, or basic
research; (2) fundamental insights into protein design and engineering, and a wealth of knowledge on the
factors that dictate protein stability and folding.