Defining the function of the thrombin receptor, PAR4, on human platelets

Project: Research

Status	Finished
Effective start/end date	1/01/13 → 31/12/15

Disrupting the platelet internal membrane via PI3KC2α inhibition impairs thrombosis independently of canonical platelet activation
Selvadurai, M. V., Moon, M. J., Mountford, S. J., Ma, X., Zheng, Z., Jennings, I. G., Setiabakti, N. M., Iman, R. P., Brazilek, R. J., Z Abidin, N. A., Chicanne, G., Severin, S., Nicholls, A. J., Wong, C. H. Y., Rinckel, J-Y., Eckly, A., Gachet, C., Nesbitt, W. S., Thompson, P. E. & Hamilton, J. R., 22 Jul 2020, In: Science Translational Medicine. 12, 553, 15 p., eaar8430.
Research output: Contribution to journal › Article › Research › peer-review

22 Citations (Scopus)
The PI 3-kinase PI3KC2α regulates mouse platelet membrane structure and function independently of membrane lipid composition
Selvadurai, M. V., Brazilek, R. J., Moon, M. J., Rinckel, J. Y., Eckly, A., Gachet, C., Meikle, P. J., Nandurkar, H. H., Nesbitt, W. S. & Hamilton, J. R., 1 Jan 2019, In: FEBS Letters. 593, 1, p. 88-96 9 p.
Research output: Contribution to journal › Article › Research › peer-review

11 Citations (Scopus)
A function-blocking PAR4 antibody is markedly antithrombotic in the face of a hyperreactive PAR4 variant
French, S. L., Thalmann, C., Bray, P. F., Macdonald, L. E., Murphy, A. J., Sleeman, M. W. & Hamilton, J. R., 12 Jun 2018, In: Blood Advances. 2, 11, p. 1283-1293 11 p.
Research output: Contribution to journal › Article › Research › peer-review

24 Citations (Scopus)

Project Details