Defining a role for non-coding RNAs in gonadal sex differentiation.

Project: Research

Project Details

Project Description

This project aims to enhance knowledge in the area of developmental biology, studying how gene regulation by
so-called non-coding RNAs contributes to tissue patterning. A unique model system will be used for which we
have an international reputation: gonadal development in the chicken embryo. Novel molecular approaches that
exploit the chicken model will be used to study the role of microRNAs and a long non-coding RNA in patterning
the embryonic gonad. The project will provide a deeper understanding of how genes operate to control tissue
patterning and organogenesis. It will inform the field of sex determination specifically, and, more broadly, stem cell
biology and tissue engineering.
StatusFinished
Effective start/end date1/01/1631/12/18

Funding

  • Australian Research Council (ARC): A$327,800.00
  • Monash University
  • FOXL2 antagonises the male developmental pathway in embryonic chicken gonads

    Major, A. T., Ayers, K. L., Chue, J., Roeszler, K. N. & Smith, C. A., Dec 2019, In: Journal of Endocrinology. 243, 3, p. 211-228 18 p.

    Research output: Contribution to journalArticleResearchpeer-review

    20 Citations (Scopus)
  • Limb patterning genes and heterochronic development of the emu wing bud

    Smith, C. A., Farlie, P. G., Davidson, N. M., Roeszler, K. N., Hirst, C., Oshlack, A. & Lambert, D. M., 20 Dec 2016, In: EvoDevo. 7, 1, 17 p., 26.

    Research output: Contribution to journalArticleResearchpeer-review

    Open Access
    File
    7 Citations (Scopus)
  • Third Report on Chicken Genes and Chromosomes 2015

    Schmid, M., Smith, J., Burt, D. W., Aken, B. L., Antin, P. B., Archibald, A. L., Ashwell, C., Blackshear, P. J., Boschiero, C., Brown, C. T., Burgess, S. C., Cheng, H. H., Chow, W., Coble, D. J., Cooksey, A., Crooijmans, R. P. M. A., Damas, J., Davis, R. V. N., De Koning, D-J., Delany, M. E., & 83 othersDerrien, T., Desta, T. T., Dunn, I. C., Dunn, M., Ellegren, H., Eory, L. A., Erb, I., Farre, M., Fasold, M., Fleming, D., Flicek, P., Fowler, K. E., Fresard, L., Froman, D. P., Garceau, V., Gardner, P. P., Gheyas, A. A., Griffin, D. K., Groenen, M. A. M., Haaf, T., Hanotte, O. H., Hart, A. W., Hasler, J., Hedges, S. B., Hertel, J., Howe, K. L., Hubbard, A. J., Hume, D. A., Kaiser, P. C., Kedra, D. A., Kemp, S. J., Klopp, C., Kniel, K. E., Kuo, R., Lagarrigue, S., Lamont, S. J., Larkin, D. M., Lawal, R. A., Markland, S. M., McCarthy, F. M., McCormack, H. A., McPherson, M. C., Motegi, A., Muljo, S. A., Munsterberg, A. E., Nag, R., Nanda, I., Neuberger, M. S., Nitsche, A., Notredame, C., Noyes, H., O'Connor, R., O'Hare, E. A., Oler, A. J., Ommeh, S. C., Pais, H. C., Persia, M., Pitel, F., Preeyanon, L., Prieto Barja, P., Pritchett, E. M., Rhoads, D. D., Robinson, C. M., Romanov, M. N., Rothschild, M. F., Roux, P-F. F., Schmidt, C. J., Schneider, A-S. S., Schwartz, M. G., Searle, S. M. J., Skinner, M. A., Smith, C. A., Stadler, P. F., Steeves, T. E., Steinlein, C., Sun, L., Takata, M., Ulitsky, I., Wang, Q., Warren, W. C., Wood, J. M. D., Wragg, D. & Zhou, H., 2015, In: Cytogenetic and Genome Research. 145, 2, p. 78-179 102 p.

    Research output: Contribution to journalArticleResearchpeer-review

    55 Citations (Scopus)