Project Details
Project Description
This project aims to discover new chiral transition-metal catalysts for the selective functionalisation of unreactive carbon-hydrogen bonds within organic molecules. A combination of statistical modelling techniques and asymmetric synthesis tactics will be harnessed to generate a data rich feedback loop that establishes an innovative platform for predictable catalyst design. Ultimately, this research is expected to deliver new catalytic processes that deliver cost savings and reduced environmental impact for the synthesis of valuable chiral amines that will find application in the development of new agrochemicals, life-saving medicines, and functional materials including photonics.
| Status | Active |
|---|---|
| Effective start/end date | 29/05/24 → 28/05/27 |
Funding
- ARC - Australian Research Council: A$460,000.00
- University of Victoria (Canada)
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Ligand-Enabled CpERhIII-Catalyzed C(sp3)–H Alkynylation of Carboxamides
Tong, Y., Ross, H. J., Day, A. J. & Priebbenow, D. L., 6 Mar 2026, In: ACS Catalysis. 16, 5, p. 4815-4826 12 p.Research output: Contribution to journal › Article › Research › peer-review
1 Link opens in a new tab Citation (Scopus) -
Acylsilanes as Weakly Coordinating Directing Groups for Metal-Catalyzed C-H Functionalization
Pilkington, R. L. & Priebbenow, D. L., 2 May 2025, In: ACS Catalysis. 15, 9, p. 6881-6894 14 p.Research output: Contribution to journal › Review Article › Research › peer-review
9 Link opens in a new tab Citations (Scopus) -
Distal C(sp3)-H Amidation via Ind*RhIII Catalyzed Nitrene Transfer
Ross, H. J., Yu, Y., Atkin, L., Ghorbani, M., Mint, K., Warne, N., Kempe, K. & Priebbenow, D. L., 16 Jul 2025, In: Journal of the American Chemical Society. 147, 28, p. 24734–24746 13 p.Research output: Contribution to journal › Article › Research › peer-review
10 Link opens in a new tab Citations (Scopus)
Equipment
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Australian Translational Medicinal Chemistry Facility (ATMCF)
Stupple, P. (Manager)
Faculty of Pharmacy and Pharmaceutical SciencesFacility/equipment: Facility
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Monash Fragment Platform (MFP)
Doak, B. (Manager) & Scanlon, M. (Manager)
Faculty of Pharmacy and Pharmaceutical SciencesFacility/equipment: Facility