Creating a MPSIII zebrafish model and brain specific in vivo lysosome reporter for drug screening and in vivo imaging of disease pathology

Kaslin, Jan (Primary Chief Investigator (PCI))
Currie, Peter (Associate Investigator (AI))

Australian Regenerative Medicine Institute

Project: Research

Project Description

We propose to use our expertise in the zebrafish disease modelling, stem cells and tissue repair to create models to study MPSIII. The glycosaminoglycan metabolism pathway including the lysosomal enzymes that are causing MPSIII variants are fully conserved in zebrafish.

Status	Finished
Effective start/end date	1/02/18 → 31/01/19

AquaCore
Crossman, S. (Manager)
Australian Regenerative Medicine Institute
Facility/equipment: Facility
Monash Micro Imaging (MMI)
Firth, S. (Manager), Fulcher, A. (Operator), Chernyavskiy, O. (Operator), Rzeszutek, M. (Other), Potter, D. (Manager), Hilsenstein, V. (Operator), Nunez-Iglesias, J. (Other), Cody, S. (Manager), Carmichael, I. (Operator), Kouskousis, B. (Other), Creed, S. (Manager) & Ballerin, G. (Operator)
Faculty of Medicine Nursing and Health Sciences Research Platforms
Facility/equipment: Facility

Creating a MPSIII zebrafish model and brain specific in vivo lysosome reporter for drug screening and in vivo imaging of disease pathology

Project Details

Project Description

Equipment

AquaCore

Monash Micro Imaging (MMI)