Combined utilisation of Rho-kinase and LDL-receptor inhibitors and targeted drug delivery by liposomes to preserve blood-brain barrier integrity and reduce bleeding complications during t-PA-triggered

Niego, Be'eri (Primary Chief Investigator (PCI))

Australian Centre for Blood Diseases

Project: Research

Status	Finished
Effective start/end date	1/01/16 → 31/12/17

Funding

Monash University – Internal School Contribution: A$20,000.00
National Heart Foundation of Australia: A$170,000.00

3 Article

T-PA suppresses the immune response and aggravates neurological deficit in a murine model of ischemic stroke
Draxler, D. F., Lee, F., Ho, H., Keragala, C. B., Medcalf, R. L. & Niego, B., 27 Mar 2019, In: Frontiers in Immunology. 10, MAR, 12 p., 591.
Research output: Contribution to journal › Article › Research › peer-review

Open Access
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20 Citations (Scopus)
LDL receptor blockade reduces mortality in a mouse model of ischaemic stroke without improving tissue-type plasminogen activator-induced brain haemorrhage: Towards pre-clinical simulation of symptomatic ICH
Niego, B., Broughton, B. R. S., Ho, H., Sobey, C. G. & Medcalf, R. L., 21 Nov 2017, In: Fluids and Barriers of the CNS. 14, 1, 11 p., 33.
Research output: Contribution to journal › Article › Research › peer-review

Open Access
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7 Citations (Scopus)
Selective inhibition of brain endothelial Rho-kinase-2 provides optimal protection of an in vitro blood-brain barrier from tissue-type plasminogen activator and plasmin
Niego, B., Lee, N., Larsson, P., De Silva, T. M., Au, A. E. L., McCutcheon, F. & Medcalf, R. L., 1 May 2017, In: PLoS ONE. 12, 5, 21 p., e0177332.
Research output: Contribution to journal › Article › Research › peer-review

Open Access
File

33 Citations (Scopus)