Combined utilisation of Rho-kinase and LDL-receptor inhibitors and targeted drug delivery by liposomes to preserve blood-brain barrier integrity and reduce bleeding complications during t-PA-triggered

Niego, Be'eri (Primary Chief Investigator (PCI))

Australian Centre for Blood Diseases

Project: Research

Status	Finished
Effective start/end date	1/01/16 → 31/12/17

Funding

Monash University – Internal School Contribution: A$20,000.00
National Heart Foundation of Australia: A$170,000.00

4 Article

T-PA suppresses the immune response and aggravates neurological deficit in a murine model of ischemic stroke
Draxler, D. F., Lee, F., Ho, H., Keragala, C. B., Medcalf, R. L. & Niego, B., 27 Mar 2019, In: Frontiers in Immunology. 10, MAR, 12 p., 591.
Research output: Contribution to journal › Article › Research › peer-review

Open Access
File

21 Citations (Scopus)
LDL receptor blockade reduces mortality in a mouse model of ischaemic stroke without improving tissue-type plasminogen activator-induced brain haemorrhage: Towards pre-clinical simulation of symptomatic ICH
Niego, B., Broughton, B. R. S., Ho, H., Sobey, C. G. & Medcalf, R. L., 21 Nov 2017, In: Fluids and Barriers of the CNS. 14, 1, 11 p., 33.
Research output: Contribution to journal › Article › Research › peer-review

Open Access
File

8 Citations (Scopus)
Novel thrombolytic drug based on thrombin cleavable microplasminogen coupled to a single-chain antibody specific for activated GPIIb/IIIa
Bonnard, T., Tennant, Z., Niego, BE., Kanojia, R., Alt, K., Jagdale, S., Law, L. S., Rigby, S., Medcalf, R. L., Peter, K. & Hagemeyer, C. E., 2017, In: Journal of the American Heart Association. 6, 2, 28 p., e004535.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

21 Citations (Scopus)