Combined utilisation of Rho-kinase and LDL-receptor inhibitors and targeted drug delivery by liposomes to preserve blood-brain barrier integrity and reduce bleeding complications during t-PA-triggered

Project: Research

StatusFinished
Effective start/end date1/01/16 → 31/12/17

Funding

  • Monash University – Internal School Contribution: AUD20,000.00
  • The Heart Foundation: AUD170,000.00
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Research Output

LDL receptor blockade reduces mortality in a mouse model of ischaemic stroke without improving tissue-type plasminogen activator-induced brain haemorrhage: Towards pre-clinical simulation of symptomatic ICH

Research output: Contribution to journal › Article › Research › peer-review

T-PA suppresses the immune response and aggravates neurological deficit in a murine model of ischemic stroke

Research output: Contribution to journal › Article › Research › peer-review

Selective inhibition of brain endothelial Rho-kinase-2 provides optimal protection of an in vitro blood-brain barrier from tissue-type plasminogen activator and plasmin

Research output: Contribution to journal › Article › Research › peer-review