| Status | Finished |
|---|---|
| Effective start/end date | 1/01/14 → 31/12/17 |
Funding
- National Health & Medical Research Council (NHMRC): AUD404,884.00
- National Health & Medical Research Council (NHMRC)
Related content
Research Output
Conjugation of 10 kDa linear PEG onto trastuzumab Fab′ is sufficient to significantly enhance lymphatic exposure while preserving in vitro biological activity
Research output: Contribution to journal › Article › Research › peer-review
Pharmacokinetics/pharmacodynamics of systemically administered polymyxin B against Klebsiella pneumoniae in mouse thigh and lung infection models
Research output: Contribution to journal › Article › Research › peer-review
Optimizing polymyxin combinations against resistant gram-negative bacteria
Research output: Contribution to journal › Article › Research › peer-review
Lithium in paediatric patients with bipolar disorder: implications for selection of dosage regimens via population pharmacokinetics/pharmacodynamics
Research output: Contribution to journal › Article › Research › peer-review
Evaluation of pharmacokinetic/pharmacodynamic model-based optimized combination regimens against multidrug-resistant Pseudomonas aeruginosa in a murine thigh infection model by using humanized dosing schemes
Research output: Contribution to journal › Article › Research › peer-review
Optimization and evaluation of piperacillin-tobramycin combination dosage regimens against Pseudomonas aeruginosa for patients with altered pharmacokinetics via the hollow-fiber infection model and mechanism-based modeling
Research output: Contribution to journal › Article › Research › peer-review
Elucidation of the pharmacokinetic/pharmacodynamic determinants of fosfomycin activity against Pseudomonas aeruginosa using a dynamic in vitro model
Research output: Contribution to journal › Article › Research › peer-review
Differences in suppression of regrowth and resistance despite similar initial bacterial killing for meropenem and piperacillin/tazobactam against Pseudomonas aeruginosa and Escherichia coli
Research output: Contribution to journal › Article › Research › peer-review
Four Decades of β-Lactam Antibiotic Pharmacokinetics in Cystic Fibrosis
Research output: Contribution to journal › Article › Research › peer-review
Paradoxical effect of polymyxin B: high drug exposure amplifies resistance in Acinetobacter baumannii
Research output: Contribution to journal › Article › Research › peer-review
Substantial targeting advantage achieved by pulmonary administration of colistin methanesulfonate in a large-animal model
Research output: Contribution to journal › Article › Research › peer-review
Substantial impact of altered pharmacokinetics in critically Ill patients on the antibacterial effects of meropenem evaluated via the dynamic hollow-fiber infection model
Research output: Contribution to journal › Article › Research › peer-review
External manipulation of nanostructure in photoresponsive lipid depot matrix to control and predict drug release in vivo
Research output: Contribution to journal › Article › Research › peer-review
Colistin and doripenem combinations against Pseudomonas aeruginosa: profiling the time course of synergistic killing and prevention of resistance
Research output: Contribution to journal › Article › Research › peer-review
Extracorporeal clearance of colistin methanesulphonate and formed colistin in end-stage renal disease patients receiving intermittent haemodialysis: implications for dosing
Research output: Contribution to journal › Article › Research › peer-review
Comparative pharmacodynamics of four different carbapenems in combination with polymyxin B against carbapenem-resistant Acinetobacter baumannii
Research output: Contribution to journal › Article › Research › peer-review
Optimization of a meropenem-tobramycin combination dosage regimen against hypermutable and nonhypermutable pseudomonas aeruginosa via mechanism-based modeling and the hollow-fiber infection model
Research output: Contribution to journal › Article › Research › peer-review
Optimization of synergistic combination regimens against carbapenem- and aminoglycoside-resistant clinical Pseudomonas aeruginosa isolates via mechanism-based pharmacokinetic/pharmacodynamic modeling
Research output: Contribution to journal › Article › Research › peer-review
Clinically relevant concentrations of fosfomycin combined with polymyxin B, tobramycin or ciprofloxacin enhance bacterial killing of Pseudomonas aeruginosa, but do not suppress the emergence of fosfomycin resistance
Research output: Contribution to journal › Article › Research › peer-review
Population Pharmacokinetics of Intravenous Colistin in Pediatric Patients: Implications for the Selection of Dosage Regimens
Research output: Contribution to journal › Article › Research › peer-review
Shape does matter: short high-concentration exposure minimizes resistance emergence for fluoroquinolones in Pseudomonas aeruginosa
Research output: Contribution to journal › Article › Research › peer-review
Stability and controlled antibiotic release from thin films embedded with antibiotic loaded mesoporous silica nanoparticles
Research output: Contribution to journal › Article › Research › peer-review
Population pharmacokinetic modeling of the enterohepatic recirculation of fimasartan in rats, dogs, and humans
Research output: Contribution to journal › Article › Research › peer-review
Meropenem Combined with Ciprofloxacin Combats Hypermutable Pseudomonas aeruginosa from Respiratory Infections of Cystic Fibrosis Patients
Research output: Contribution to journal › Article › Research › peer-review
Two mechanisms of killing of Pseudomonas aeruginosa by tobramycin assessed at multiple inocula via mechanism-based modeling
Research output: Contribution to journal › Article › Research › peer-review
Characterizing the time-course of antihypertensive activity and optimal dose range of fimasartan via mechanism-based population modeling
Research output: Contribution to journal › Article › Research › peer-review
Characterization of Hypermutator Pseudomonas aeruginosa Isolates from Patients with Cystic Fibrosis in Australia
Research output: Contribution to journal › Article › Research › peer-review
Colistin: how should It Be dosed for the critically ill?
Research output: Contribution to journal › Article › Research › peer-review
Aminoglycoside concentrations required for synergy with carbapenems against Pseudomonas aeruginosa determined via mechanistic studies and modeling
Research output: Contribution to journal › Article › Research › peer-review
Combating Carbapenem-Resistant Acinetobacter baumannii by an Optimized Imipenem-plus-Tobramycin Dosage Regimen: Prospective Validation via Hollow-Fiber Infection and Mathematical Modeling
Research output: Contribution to journal › Article › Research › peer-review
Effect of different renal function on antibacterial effects of piperacillin against Pseudomonas aeruginosa evaluated via the hollow-fibre infection model and mechanism-based modelling
Research output: Contribution to journal › Article › Research › peer-review
Prolonged and continuous antibacterial and anti-biofilm activities of thin films embedded with gentamicin-loaded mesoporous silica nanoparticles
Research output: Contribution to journal › Article › Research › peer-review
Novel approach to optimize synergistic carbapenem-aminoglycoside combinations against carbapenem-resistant Acinetobacter baumannii
Research output: Contribution to journal › Article › Research › peer-review
PEGylated interferon displays differences in plasma clearance and bioavailability between male and female mice and between female immunocompetent C57Bl/6J and athymic nude mice
Research output: Contribution to journal › Article › Research › peer-review
Resistance suppression by high-intensity, short-duration aminoglycoside exposure against hypermutable and non-hypermutable Pseudomonas aeruginosa
Research output: Contribution to journal › Article › Research › peer-review