| Status | Finished |
|---|---|
| Effective start/end date | 1/01/14 → 31/12/17 |
Funding
- National Health & Medical Research Council (NHMRC): AUD404,884.00
- National Health & Medical Research Council (NHMRC)
Related content
Research Output
Optimizing polymyxin combinations against resistant gram-negative bacteria
Research output: Contribution to journal › Article › Research › peer-review
Colistin: how should It Be dosed for the critically ill?
Research output: Contribution to journal › Article › Research › peer-review
Elucidation of the pharmacokinetic/pharmacodynamic determinants of fosfomycin activity against Pseudomonas aeruginosa using a dynamic in vitro model
Research output: Contribution to journal › Article › Research › peer-review
Characterization of Hypermutator Pseudomonas aeruginosa Isolates from Patients with Cystic Fibrosis in Australia
Research output: Contribution to journal › Article › Research › peer-review
Conjugation of 10 kDa linear PEG onto trastuzumab Fab′ is sufficient to significantly enhance lymphatic exposure while preserving in vitro biological activity
Research output: Contribution to journal › Article › Research › peer-review
Pharmacokinetics/pharmacodynamics of systemically administered polymyxin B against Klebsiella pneumoniae in mouse thigh and lung infection models
Research output: Contribution to journal › Article › Research › peer-review
Aminoglycoside concentrations required for synergy with carbapenems against Pseudomonas aeruginosa determined via mechanistic studies and modeling
Research output: Contribution to journal › Article › Research › peer-review
Combating Carbapenem-Resistant Acinetobacter baumannii by an Optimized Imipenem-plus-Tobramycin Dosage Regimen: Prospective Validation via Hollow-Fiber Infection and Mathematical Modeling
Research output: Contribution to journal › Article › Research › peer-review
Shape does matter: short high-concentration exposure minimizes resistance emergence for fluoroquinolones in Pseudomonas aeruginosa
Research output: Contribution to journal › Article › Research › peer-review
Two mechanisms of killing of Pseudomonas aeruginosa by tobramycin assessed at multiple inocula via mechanism-based modeling
Research output: Contribution to journal › Article › Research › peer-review
Prolonged and continuous antibacterial and anti-biofilm activities of thin films embedded with gentamicin-loaded mesoporous silica nanoparticles
Research output: Contribution to journal › Article › Research › peer-review
Optimization of a meropenem-tobramycin combination dosage regimen against hypermutable and nonhypermutable pseudomonas aeruginosa via mechanism-based modeling and the hollow-fiber infection model
Research output: Contribution to journal › Article › Research › peer-review
Extracorporeal clearance of colistin methanesulphonate and formed colistin in end-stage renal disease patients receiving intermittent haemodialysis: implications for dosing
Research output: Contribution to journal › Article › Research › peer-review
PEGylated interferon displays differences in plasma clearance and bioavailability between male and female mice and between female immunocompetent C57Bl/6J and athymic nude mice
Research output: Contribution to journal › Article › Research › peer-review
Population pharmacokinetic modeling of the enterohepatic recirculation of fimasartan in rats, dogs, and humans
Research output: Contribution to journal › Article › Research › peer-review
Meropenem Combined with Ciprofloxacin Combats Hypermutable Pseudomonas aeruginosa from Respiratory Infections of Cystic Fibrosis Patients
Research output: Contribution to journal › Article › Research › peer-review
External manipulation of nanostructure in photoresponsive lipid depot matrix to control and predict drug release in vivo
Research output: Contribution to journal › Article › Research › peer-review
Effect of different renal function on antibacterial effects of piperacillin against Pseudomonas aeruginosa evaluated via the hollow-fibre infection model and mechanism-based modelling
Research output: Contribution to journal › Article › Research › peer-review
Characterizing the time-course of antihypertensive activity and optimal dose range of fimasartan via mechanism-based population modeling
Research output: Contribution to journal › Article › Research › peer-review
Novel approach to optimize synergistic carbapenem-aminoglycoside combinations against carbapenem-resistant Acinetobacter baumannii
Research output: Contribution to journal › Article › Research › peer-review
Colistin and doripenem combinations against Pseudomonas aeruginosa: profiling the time course of synergistic killing and prevention of resistance
Research output: Contribution to journal › Article › Research › peer-review
Resistance suppression by high-intensity, short-duration aminoglycoside exposure against hypermutable and non-hypermutable Pseudomonas aeruginosa
Research output: Contribution to journal › Article › Research › peer-review
Substantial targeting advantage achieved by pulmonary administration of colistin methanesulfonate in a large-animal model
Research output: Contribution to journal › Article › Research › peer-review
Substantial impact of altered pharmacokinetics in critically Ill patients on the antibacterial effects of meropenem evaluated via the dynamic hollow-fiber infection model
Research output: Contribution to journal › Article › Research › peer-review
Four Decades of β-Lactam Antibiotic Pharmacokinetics in Cystic Fibrosis
Research output: Contribution to journal › Article › Research › peer-review
Stability and controlled antibiotic release from thin films embedded with antibiotic loaded mesoporous silica nanoparticles
Research output: Contribution to journal › Article › Research › peer-review
Lithium in paediatric patients with bipolar disorder: implications for selection of dosage regimens via population pharmacokinetics/pharmacodynamics
Research output: Contribution to journal › Article › Research › peer-review
Comparative pharmacodynamics of four different carbapenems in combination with polymyxin B against carbapenem-resistant Acinetobacter baumannii
Research output: Contribution to journal › Article › Research › peer-review
Clinically relevant concentrations of fosfomycin combined with polymyxin B, tobramycin or ciprofloxacin enhance bacterial killing of Pseudomonas aeruginosa, but do not suppress the emergence of fosfomycin resistance
Research output: Contribution to journal › Article › Research › peer-review
Paradoxical effect of polymyxin B: high drug exposure amplifies resistance in Acinetobacter baumannii
Research output: Contribution to journal › Article › Research › peer-review
Evaluation of pharmacokinetic/pharmacodynamic model-based optimized combination regimens against multidrug-resistant Pseudomonas aeruginosa in a murine thigh infection model by using humanized dosing schemes
Research output: Contribution to journal › Article › Research › peer-review
Optimization of synergistic combination regimens against carbapenem- and aminoglycoside-resistant clinical Pseudomonas aeruginosa isolates via mechanism-based pharmacokinetic/pharmacodynamic modeling
Research output: Contribution to journal › Article › Research › peer-review
Optimization and evaluation of piperacillin-tobramycin combination dosage regimens against Pseudomonas aeruginosa for patients with altered pharmacokinetics via the hollow-fiber infection model and mechanism-based modeling
Research output: Contribution to journal › Article › Research › peer-review
Differences in suppression of regrowth and resistance despite similar initial bacterial killing for meropenem and piperacillin/tazobactam against Pseudomonas aeruginosa and Escherichia coli
Research output: Contribution to journal › Article › Research › peer-review