Research output per year
Research output per year
Project Details
Project Description
Gonad formation during embryonic life provides an excellent model for studying the genetic control of
development. This project aims to enhance our understanding of gonad formation (testis vs ovary development) at
the genetic level, using unique approaches that exploit the chicken embryo as a model system. Innovative
methods will be used to study novel and known gonad-determining genes. The project is expected to make a
substantial contribution to our understanding of cell fate decisions, sex determination and gonad development. It
is also anticipated to have application to the poultry industry by illuminating those genes and pathways that can be
targeted to modulate sex determination in chickens, which is a goal of the industry.
development. This project aims to enhance our understanding of gonad formation (testis vs ovary development) at
the genetic level, using unique approaches that exploit the chicken embryo as a model system. Innovative
methods will be used to study novel and known gonad-determining genes. The project is expected to make a
substantial contribution to our understanding of cell fate decisions, sex determination and gonad development. It
is also anticipated to have application to the poultry industry by illuminating those genes and pathways that can be
targeted to modulate sex determination in chickens, which is a goal of the industry.
| Status | Finished |
|---|---|
| Effective start/end date | 1/01/16 → 31/12/18 |
Funding
- Australian Research Council (ARC): A$364,800.00
- Monash University
- Hokkaido University
Research output
- 5 Article
-
Adhesion G-protein-coupled receptor, GPR56, is required for Müllerian duct development in the chick
Roly, Z. Y., Major, A. T., Fulcher, A., Estermann, M. A., Hirst, C. E. & Smith, C. A., Feb 2020, In: Journal of Endocrinology. 244, 2, p. 395-413 19 p.Research output: Contribution to journal › Article › Research › peer-review
8 Citations (Scopus) -
Insights into Gonadal Sex Differentiation Provided by Single-Cell Transcriptomics in the Chicken Embryo
Estermann, M. A., Williams, S., Hirst, C. E., Roly, Z. Y., Serralbo, O., Adhikari, D., Powell, D., Major, A. T. & Smith, C. A., 7 Apr 2020, In: Cell Reports. 31, 1, 19 p., 107491.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile40 Citations (Scopus) -
Transcriptional landscape of the embryonic chicken Müllerian duct
Roly, Z. Y., Godini, R., Estermann, M. A., Major, A. T., Pocock, R. & Smith, C. A., 2 Oct 2020, In: BMC Genomics. 21, 1, 22 p., 688.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile5 Citations (Scopus)