Bronsted Acid Activated Chiral Bronsted Bases: Catalysts for Enantioselective Photochemical and Aminyl Radical Reactions.

This project will explore the application of Bronsted acid activated chiral Bronsted bases as acid catalysts for a number of novel chemical transformations. This intriguing strategy is underdeveloped and should prove useful in the development of asymmetric photochemical and aminyl radical reactions. The application of these novel technologies to the synthesis of the biologically relevant Grandisine natural products, with relevance to the treatment of chronic pain, will then be investigated.