Bitopic ligands as a novel approach to G protein-coupled receptor selectivity

Lane, Jonathan (Primary Chief Investigator (PCI))

Faculty of Pharmacy and Pharmaceutical Sciences

Project: Research

Status	Finished
Effective start/end date	1/01/11 → 31/12/13

Funding

National Health and Medical Research Council (NHMRC) (Australia): A$260,853.00
National Health and Medical Research Council (NHMRC) (Australia): A$260,853.00

2 Article

Discovery of a novel class of negative allosteric modulator of the dopamine D2 receptor through fragmentation of a bitopic ligand
Mistry, S. N., Shonberg, J., Draper-Joyce, C. J., Klein Herenbrink, C., Michino, M., Shi, L., Christopoulos, A., Capuano, B., Scammells, P. J. & Lane, J. R. D., 2015, In: Journal of Medicinal Chemistry. 58, 17, p. 6819-6843 25 p.
Research output: Contribution to journal › Article › Research › peer-review

49 Citations (Scopus)
Structure-activity study of N-((trans)-4-(2-(7-cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)-1H-indole-2-carboxamide (SB269652), a bitopic ligand that acts as a negative allosteric modulator of the dopamine D2 receptor
Shonberg, J., Draper-Joyce, C. J., Mistry, S. N., Christopoulos, A., Scammells, P. J., Lane, J. R. D. & Capuano, B., 2015, In: Journal of Medicinal Chemistry. 58, 13, p. 5287 - 5307 21 p.
Research output: Contribution to journal › Article › Research › peer-review

39 Citations (Scopus)