Research output per year
Research output per year
Project Details
Project Description
Australian sea anemones are a highly promising and largely unexplored source of peptides and proteins with potential therapeutic and diagnostic applications. This project will evaluate this potential by undertaking transcriptomic analyses of a number species of anemones from Australian waters and identifying peptides and proteins in their venoms by mass spectrometry. It will also demonstrate the value of transcriptomics in informing taxonomic classification of anemones. In addition this project will assess toxin diversity within and between
species based on nematocyst function from specific tissue sources and provide a clearer understanding of the evolution of venoms in Australian Actiniaria.
species based on nematocyst function from specific tissue sources and provide a clearer understanding of the evolution of venoms in Australian Actiniaria.
| Status | Finished |
|---|---|
| Effective start/end date | 29/12/15 → 28/07/18 |
Funding
- Australian Research Council (ARC): A$174,000.00
- Monash University
- Museums Board of Victoria (trading as Museums Victoria)
- Queensland Museum
- Walter and Eliza Hall Institute of Medical Research (WEHI)
-
Genomic, functional and structural analyses elucidate evolutionary innovation within the sea anemone 8 toxin family
Ashwood, L. M., Elnahriry, K. A., Stewart, Z. K., Shafee, T., Naseem, M. U., Szanto, T. G., van der Burg, C. A., Smith, H. L., Surm, J. M., Undheim, E. A. B., Madio, B., Hamilton, B. R., Guo, S., Wai, D. C. C., Coyne, V. L., Phillips, M. J., Dudley, K. J., Hurwood, D. A., Panyi, G. & King, G. F. & 3 others, , 24 May 2023, In: BMC Biology. 21, 1, 25 p., 121.Research output: Contribution to journal › Article › Research › peer-review
Open Access10 Citations (Scopus) -
Identification, synthesis, conformation and activity of an insulin‐like peptide from a sea anemone
Mitchell, M. L., Hossain, M. A., Lin, F., Pinheiro‐junior, E. L., Peigneur, S., Wai, D. C. C., Delaine, C., Blyth, A. J., Forbes, B. E., Tytgat, J., Wade, J. D. & Norton, R. S., Dec 2021, In: Biomolecules. 11, 12, 16 p., 1785.Research output: Contribution to journal › Article › Research › peer-review
Open Access13 Citations (Scopus) -
Tentacle morphological variation coincides with differential expression of toxins in sea anemones
Ashwood, L. M., Mitchell, M. L., Madio, B., Hurwood, D. A., King, G. F., Undheim, E. A. B., Norton, R. S. & Prentis, P. J., Jul 2021, In: Toxins. 13, 7, 18 p., 452.Research output: Contribution to journal › Article › Research › peer-review
Open Access14 Citations (Scopus)