The project aims to reveal how mylination is dynamically regulated by neural activity throughout life. Using an innovative multi-disciplinary approach incorporating animal studies, mathematical modelling and computational neuroscience, this project seeks to redifine our understanding of mylination as a key driver of brain plasticity using an entirely new integrated cell-to-system approach. The expected outcome is fundamental knowledge revealing how myelin plasticity optimises brain function in response to experience. The benefit will be the creation of a world-class laboratory focused on myelin remodelling. This will transform current understanding of neuroplasticity that could aid the development of strategies to improve brain health.