Assessing human kidney organoids as a replacement for mouse models of renal fibrosis

Project: Research

Project Details

Project Description

In this project we will test the capacity of miniature human kidney tissues ‘organoids’ to model kidney injury and replicate the early sequence of events that initiates a fibrotic response in humans. If successful, our human kidney organoid model will provide a new platform to accelerate the development of antifibrotic therapies to retain renal function in patients suffering from chronic kidney disease.
StatusActive
Effective start/end date30/06/211/08/24

Keywords

  • Fibrosis
  • Disease modelling
  • Kidney organoids
  • Directed differentiation
  • Chronic kidney disease
  • Acute kidney injury