Are neurobehavioural and neuromotor impairments associated with FMR1 gene expansion?

  • Cornish, Kim (Primary Chief Investigator (PCI))
  • Bradshaw, John (Chief Investigator (CI))
  • Fielding, Joanne (Chief Investigator (CI))
  • Georgiou-Karistianis, Nellie (Chief Investigator (CI))
  • Iansek, Robert (Chief Investigator (CI))
  • Metcalfe, Sylvia (Chief Investigator (CI))
  • Trollor, Julian Norman (Chief Investigator (CI))
  • Wen, Wei (Chief Investigator (CI))
  • Delatycki, Martin (Partner Investigator (PI))
  • Hackett, Anna (Partner Investigator (PI))

Project: Research

Project Details

Project Description

Fragile X syndrome is caused by the silencing of a single gene on the X chromosome whose protein product
influences multiple aspects of cortical development. The gene, called FMR1, is present in all of us. In Fragile
X syndrome, there is a large expansion of the gene. Our previous work revealed that many other individuals
who have small and medium expansion ranges may also be vulnerable to cognitive and brain impairments.
Our aim is to provide a unique framework to identify age and gender-specific trajectories of function and dysfunction at multiple levels: from gene expression to brain and cognitive networks and from gene expression to the environment.
Effective start/end date4/01/1130/10/14


  • Australian Research Council (ARC): A$800,000.00
  • University of Melbourne
  • University of New South Wales (UNSW)