| Status | Finished |
|---|---|
| Effective start/end date | 1/01/12 → 31/12/16 |
Funding
- National Health & Medical Research Council (NHMRC): AUD696,210.00
- National Health & Medical Research Council (NHMRC): AUD974,695.00
Related content
Research Output
IMiDs prime myeloma cells for daratumumab-mediated cytotoxicity through loss of Ikaros and Aiolos
Research output: Contribution to journal › Article › Research › peer-review
Translation inhibitors induce cell death by multiple mechanisms and Mcl-1 reduction is only a minor contributor
Research output: Contribution to journal › Article › Research › peer-review
VDAC2 enables BAX to mediate apoptosis and limit tumor development
Research output: Contribution to journal › Article › Research › peer-review
The NF-κB transcription factor RelA is required for the tolerogenic function of Foxp3+ regulatory T cells
Research output: Contribution to journal › Article › Research › peer-review
Proapoptotic BIM impacts B lymphoid homeostasis by limiting the survival of mature B cells in a cell-autonomous manner
Research output: Contribution to journal › Article › Research › peer-review
A transgenic mouse model to inducibly target prosurvival Bcl2 proteins with selective BH3 peptides in vivo
Research output: Contribution to journal › Letter › Research › peer-review
Cycloheximide can induce bax/bak dependent myeloid cell death independently of multiple BH3-only proteins
Research output: Contribution to journal › Article › Research › peer-review
Essential role for a novel population of binucleated mammary epithelial cells in lactation
Research output: Contribution to journal › Article › Research › peer-review
Hierarchy for targeting prosurvival BCL2 family proteins in multiple myeloma: Pivotal role of MCL1
Research output: Contribution to journal › Article › Research › peer-review
Loss of PUMA (BBC3) does not prevent thrombocytopenia caused by the loss of BCL-XL (BCL2L1)
Research output: Contribution to journal › Article › Research › peer-review
PTPN2 regulates T cell lineage commitment and αß versus γδ specification
Research output: Contribution to journal › Article › Research › peer-review
Cisplatin- and cyclophosphamide-induced primordial follicle depletion is caused by direct damage to oocytes
Research output: Contribution to journal › Article › Research › peer-review
Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies
Research output: Contribution to journal › Article › Research › peer-review
NFκB1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cells
Research output: Contribution to journal › Article › Research › peer-review
Dynein light chain regulates adaptive and innate B cell development by distinctive genetic mechanisms
Research output: Contribution to journal › Article › Research › peer-review
Impact of loss of NF-κB1, NF-κB2 or c-REL on SLE-like autoimmune disease and lymphadenopathy in Faslpr/lpr mutant mice
Research output: Contribution to journal › Article › Research › peer-review
Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to maintain survival of immune cell populations both in vitro and in vivo
Research output: Contribution to journal › Article › Research › peer-review
Eliminating Legionella by inhibiting BCL-XL to induce macrophage apoptosis
Research output: Contribution to journal › Article › Research › peer-review
The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models
Research output: Contribution to journal › Article › Research › peer-review
Defining a therapeutic window for kinase inhibitors in leukemia to avoid neutropenia
Research output: Contribution to journal › Article › Research › peer-review
Subtle Changes in the Levels of BCL-2 Proteins Cause Severe Craniofacial Abnormalities
Research output: Contribution to journal › Article › Research › peer-review
PUMA promotes apoptosis of hematopoietic progenitors driving leukemic progression in a mouse model of myelodysplasia
Research output: Contribution to journal › Article › Research › peer-review
The ovarian reserve is depleted during puberty in a hormonally driven process dependent on the pro-Apoptotic protein BMF
Research output: Contribution to journal › Article › Research › peer-review
Loss of PUMA protects the ovarian reserve during DNA-damaging chemotherapy and preserves fertility
Research output: Contribution to journal › Article › Research › peer-review
Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics
Research output: Contribution to journal › Article › Research › peer-review
Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming
Research output: Contribution to journal › Article › Research › peer-review
BCL-2 is dispensable for thrombopoiesis and platelet survival
Research output: Contribution to journal › Article › Research › peer-review
PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemia
Research output: Contribution to journal › Article › Research › peer-review