Analyses of Neuroendocrine Differentiation in Localized Prostate Cancer.

Toivanen, Roxanne (Primary Chief Investigator (PCI))

Anatomy & Developmental Biology

Project: Research

Project Description

Neuroendocrine prostate cancers are a highly aggressive tumours that typically emerge when patients relapse from hormone therapy. Interestingly some tumours have neuroendocrine cells prior to hormone therapy, and have been studied in little detail. This proposal will investigate the properties of early stage prostate cancers with neuroendocrine cells and determine whether they exhibit similar features and aggressive behavior as end-stage therapy resistant neuroendocrine tumours.

Short title	Analyses of prostate cancers with neuroendocrine cells
Status	Finished
Effective start/end date	1/01/18 → 30/06/19

1 Article

The MURAL collection of prostate cancer patient-derived xenografts enables discovery through preclinical models of uro-oncology
Risbridger, G. P., Clark, A. K., Porter, L. H., Toivanen, R., Bakshi, A., Lister, N. L., Pook, D., Pezaro, C. J., Sandhu, S., Keerthikumar, S., Quezada Urban, R., Papargiris, M., Kraska, J., Madsen, H. B., Wang, H., Richards, M. G., Niranjan, B., O’Dea, S., Teng, L. & Wheelahan, W. & 25 others, Li, Z., Choo, N., Ouyang, J. F., Thorne, H., Devereux, L., Hicks, R. J., Sengupta, S., Harewood, L., Iddawala, M., Azad, A. A., Goad, J., Grummet, J., Kourambas, J., Kwan, E. M., Moon, D., Murphy, D. G., Pedersen, J., Clouston, D., Norden, S., Ryan, A., Furic, L., Goode, D. L., Frydenberg, M., Lawrence, M. G. & Taylor, R. A., 19 Aug 2021, In: Nature Communications. 12, 1, 5049.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

48 Citations (Scopus)

Analyses of Neuroendocrine Differentiation in Localized Prostate Cancer.

Project Details

Project Description

Research output

The MURAL collection of prostate cancer patient-derived xenografts enables discovery through preclinical models of uro-oncology