Allosteric Modulators as Novel Probes of G-Protein Coupled Receptor Function

Project: Research

Project Description

This project aims to identify novel allosteric modulators acting at the A1 adenosine receptor and the M2 muscarinic acetylcholine receptor which will be evaluated in kinetic and functional assays. Ligands will also be developed for chemical-biology studies probing the fundamental mechanisms of allosteric modulation.
StatusFinished
Effective start/end date2/01/0831/12/11

Funding

  • Australian Research Council (ARC): AUD300,000.00
  • Australian Research Council (ARC)
  • Australian Research Council (ARC)