Allosteric Fingerprinting of G Protein-Coupled Receptor Monomers and Oligomers

Search results

• 2024

  Lipidated brush-PEG polymers as low molecular weight pulmonary drug delivery platforms

  Kaminskas, L. M., Butcher, N. J., Subasic, C. N., Kothapalli, A., Haque, S., Grace, J. L., Morsdorf, A., Blanchfield, J. T., Whittaker, A. K., Quinn, J. F. & Whittaker, M. R., 23 Jan 2024, In: Expert Opinion on Drug Delivery. 21, 1, p. 151-167 17 p.

  Research output: Contribution to journal › Article › Research › peer-review

  2   Link opens in a new tab Citations (Scopus)

• 2019

  The adenosine A _2B G protein-coupled receptor: Recent advances and therapeutic implications

  Vecchio, E. A., White, P. J. & May, L. T., 1 Jan 2019, In: Pharmacology & Therapeutics. 198, p. 20-33 14 p.

  Research output: Contribution to journal › Review Article › Research › peer-review

  48   Link opens in a new tab Citations (Scopus)

• 2018

  New paradigms in adenosine receptor pharmacology: allostery, oligomerization and biased agonism

  Vecchio, E. A., Baltos, J. A., Nguyen, A. T. N., Christopoulos, A., White, P. J. & May, L. T., 1 Nov 2018, In: British Journal of Pharmacology. 175, 21, p. 4036-4046 11 p.

  Research output: Contribution to journal › Review Article › Research › peer-review

  52   Link opens in a new tab Citations (Scopus)

• α_1A-Adrenoceptors activate mTOR signalling and glucose uptake in cardiomyocytes

  Sato, M., Evans, B. A., Sandström, A. L., Chia, L. Y., Mukaida, S., Thai, B. S., Nguyen, A., Lim, L., Tan, C. Y. R., Baltos, J. A., White, P. J., May, L. T., Hutchinson, D. S., Summers, R. J. & Bengtsson, T., 1 Feb 2018, In: Biochemical Pharmacology. 148, p. 27-40 14 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

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  22   Link opens in a new tab Citations (Scopus)

• 2017

  Capadenoson, a clinically trialed partial adenosine A₁ receptor agonist, can stimulate adenosine A_2B receptor biased agonism

  Baltos, J.-A., Vecchio, E. A., Harris, M. A., Qin, C. X., Ritchie, R. H., Christopoulos, A., White, P. J. & May, L. T., 1 Jul 2017, In: Biochemical Pharmacology. 135, p. 79–89 11 p.

  Research output: Contribution to journal › Article › Research › peer-review

  42   Link opens in a new tab Citations (Scopus)

• New pharmacological approaches to the prevention of myocardial ischemia-reperfusion injury

  Chin, K. Y., Qin, C., May, L., Ritchie, R. H. & Woodman, O. L., 1 Jan 2017, In: Current Drug Targets. 18, 15, p. 1689-1711 23 p.

  Research output: Contribution to journal › Review Article › Research › peer-review

  26   Link opens in a new tab Citations (Scopus)

• Small-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in mice

  Qin, C. X., May, L. T., Li, R., Cao, N., Rosli, S., Deo, M., Alexander, A. E., Horlock, D., Bourke, J. E., Yang, Y. H., Stewart, A. G., Kaye, D. M., Du, X. J., Sexton, P. M., Christopoulos, A., Gao, X. M. & Ritchie, R. H., 7 Feb 2017, In: Nature Communications. 8, 13 p., 14232.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

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  123   Link opens in a new tab Citations (Scopus)

• Targeting adenosine receptors for the treatment of cardiac fibrosis

  Vecchio, E. A., White, P. J. & May, L. T., 5 May 2017, In: Frontiers in Pharmacology. 8, MAY, 7 p., 243.

  Research output: Contribution to journal › Review Article › Other › peer-review

  Open Access

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  47   Link opens in a new tab Citations (Scopus)

• 2016

  Extracellular loop 2 of the adenosine A₁ receptor has a key role in orthosteric ligand affinity and agonist efficacy

  Nguyen, A. T. N., Baltos, J.-A., Thomas, T., Nguyen, T. D., Lopez Munoz, L., Gregory, K. J., White, P. J., Sexton, P. M., Christopoulos, A. & May, L. T., 1 Dec 2016, In: Molecular Pharmacology. 90, 6, p. 703-714 12 p.

  Research output: Contribution to journal › Article › Research › peer-review

  43   Link opens in a new tab Citations (Scopus)

• Ligand-independent adenosine A_2B receptor constitutive activity as a promoter of prostate cancer cell proliferation

  Vecchio, E. A., Tan, C. Y. R., Gregory, K., Christopoulos, A., White, P. J. & May, L. T., 1 Apr 2016, In: Journal of Pharmacology and Experimental Therapeutics. 357, 1, p. 36-44 9 p.

  Research output: Contribution to journal › Article › Research › peer-review

  56   Link opens in a new tab Citations (Scopus)

• Role of the second extracellular loop of the adenosine A₁ receptor on allosteric modulator binding, signaling, and cooperativity

  Nguyen, A. T. N., Vecchio, E. A., Thomas, T., Nguyen, T. D., Aurelio, L., Scammells, P. J., White, P. J., Sexton, P. M., Gregory, K. J., May, L. T. & Christopoulos, A., 1 Dec 2016, In: Molecular Pharmacology. 90, 6, p. 715-725 11 p.

  Research output: Contribution to journal › Article › Research › peer-review

  43   Link opens in a new tab Citations (Scopus)

• Sarcolemmal dependence of cardiac protection and stress-resistance: roles in aged or diseased hearts

  See Hoe, L. E., May, L. T., Headrick, J. P. & Peart, J. N., Oct 2016, In: British Journal of Pharmacology. 173, 20, p. 2966-2991 26 p.

  Research output: Contribution to journal › Review Article › Research › peer-review

  8   Link opens in a new tab Citations (Scopus)

• The hybrid molecule, VCP746, is a potent adenosine A_2B receptor agonist that stimulates anti-fibrotic signalling

  Vecchio, L., Chuo, C. H., Baltos, J.-A., Ford, L., Scammells, P. J., Wang, B. H., Christopoulos, A., White, P. J. & May, L. T., 1 Oct 2016, In: Biochemical Pharmacology. 117, p. 46-56 11 p.

  Research output: Contribution to journal › Article › Research › peer-review

  34   Link opens in a new tab Citations (Scopus)

• VCP746, a novel A₁ adenosine receptor biased agonist, reduces hypertrophy in a rat neonatal cardiac myocyte model

  Chuo, C. H., Devine, S. M., Scammells, P. J., Krum, H., Christopoulos, A., May, L. T., White, P. J. & Wang, B. H., 1 Oct 2016, In: Clinical and Experimental Pharmacology and Physiology. 43, 10, p. 976-982 7 p.

  Research output: Contribution to journal › Article › Research › peer-review

  23   Link opens in a new tab Citations (Scopus)

• 2015

  A positive allosteric modulator of the adenosine A1 receptor selectively inhibits primary afferent synaptic transmission in a neuropathic pain model

  Imlach, W. L., Bhola, R. F., May, L. T., Christopoulos, A. & Christie, M. J., 2015, In: Molecular Pharmacology. 88, 3, p. 460-468 9 p.

  Research output: Contribution to journal › Article › Research › peer-review

  38   Link opens in a new tab Citations (Scopus)

• Synthesis and pharmacological evaluation of dual acting ligands targeting the adenosine A2A and dopamine D2 receptors for the potential treatment of Parkinson's disease

  Jorg, M. T., May, L. T., Mak, F. S., Lee, K. C. K., Miller, N. D., Scammells, P. J. & Capuano, B., 2015, In: Journal of Medicinal Chemistry. 58, 2, p. 718 - 738 21 p.

  Research output: Contribution to journal › Article › Research › peer-review

  54   Link opens in a new tab Citations (Scopus)