Allosteric and Bitopic Ligands Acting at G Protein-Coupled Receptors

Project: Research

Project Details

Project Description

G protein-coupled receptors (GPCRs) are an important class of membrane bound receptor that regulate a wide
range of physiological processes and are the target of over 30% of currently used pharmaceuticals. Investigation
of GPCR structure and function is an important area of endeavour and was the topic associated with the award of
the 2012 Nobel Prize for Chemistry. This project seeks to gain a more detailed fundamental understanding of the
mechanisms of GPCR function using novel chemical tools. More specifically, this research will address the
paradigm of allosteric modulation that offers exciting potential of identifying 'pathway selective' agents.
Effective start/end date1/01/1630/06/19


  • Australian Research Council (ARC): A$667,850.00
  • Monash University