Adenosine A1 receptor modulation: Structure, dynamics & novel pharmacological interventions

Christopoulos, Arthur (Primary Chief Investigator (PCI))
May, Lauren (Chief Investigator (CI))
Imlach, Wendy (Chief Investigator (CI))
Hill, Stephen (Chief Investigator (CI))
Scott, Daniel (Chief Investigator (CI))

Project: Research

Status	Finished
Effective start/end date	1/01/18 → 31/12/22

6 Article
3 Review Article

Targeting G protein-coupled receptors for heart failure treatment
Thai, B. S., Chia, L. Y., Nguyen, A. T. N., Qin, C., Ritchie, R. H., Hutchinson, D. S., Kompa, A., White, P. J. & May, L. T., Jul 2024, In: British Journal of Pharmacology. 181, 14, p. 2270-2286 17 p.
Research output: Contribution to journal › Review Article › Research › peer-review

Open Access

4 Citations (Scopus)
The application of artificial intelligence to accelerate G protein-coupled receptor drug discovery
Nguyen, A. T. N., Nguyen, D. T. N., Koh, H. Y., Toskov, J., MacLean, W., Xu, A., Zhang, D., Webb, G. I., May, L. T. & Halls, M. L., Jul 2024, In: British Journal of Pharmacology. 181, 14, p. 2371-2384 14 p.
Research output: Contribution to journal › Review Article › Research › peer-review

Open Access

15 Citations (Scopus)
Structure-based virtual screening discovers potent and selective adenosine A₁ receptor antagonists
Matricon, P., Nguyen, A. TN., Vo, D. D., Baltos, J. A., Jaiteh, M., Luttens, A., Kampen, S., Christopoulos, A., Kihlberg, J., May, L. T. & Carlsson, J., 5 Sept 2023, In: European Journal of Medicinal Chemistry. 257, 115419.
Research output: Contribution to journal › Article › Research › peer-review

Open Access

7 Citations (Scopus)

Animal Research Platform (MARP)
Christine Findlay (Manager)
Faculty of Medicine Nursing and Health Sciences Research Platforms
Facility/equipment: Facility
Centre for Drug Candidate Optimisation
Susan Charman (Other)
Pharmacy and Pharmaceutical Sciences Faculty Office
Facility/equipment: Facility
Ramaciotti Centre for Cryo-Electron Microscopy
Georg Ramm (Manager), Simon Andrew Crawford (Operator), Hariprasad Venugopal (Operator), Joan Marea Clark (Operator) & Gediminas Gervinskas (Operator)
Faculty of Medicine Nursing and Health Sciences Research Platforms
Facility/equipment: Facility