A toxic cycle of inflammation and iron in the ageing brain

  • Robinson, Stephen, (Primary Chief Investigator (PCI))
  • Bishop, Glenda Maree, (Chief Investigator (CI))

Project: Research

Project Description

This project uses a mouse model to investigate a new idea about how inflammation and iron interact to cause brain injury. We expect to show that inflammation in the body causes iron to accumulate in the brain and become toxic. We also expect to find that iron supplements and ageing make this situation worse. The results will make scientists think differently about the brain and will offer a completely new explanation of why some people remain cognitively sharp into old age while others do not. The results are certain to provide new perspectives on ageing and neurodegenerative diseases, and will expose new targets for effective therapies.
StatusFinished
Effective start/end date3/01/1231/12/14

Funding

  • Australian Research Council (ARC): AUD270,000.00
  • Australian Research Council (ARC)
  • Australian Research Council (ARC)