A tale of two genomes: integrating mitochondrial biogenesis into the cell cycle and metabolic control.

Project: Research

Project Details

Project Description

Mitochondria are essential to human cell biology, including processes such as programmed cell death and ageing. Mitochondria are also the only component of cells that depend on both the nuclear and mitochondrial genome. We will use molecular genetics, coupled with biochemistry and -omics approaches of Systems Biology to understand how the two genomes are regulated in the context of metabolism and cell division. The outcomes will be new fundamental knowledge about the coordination of mitochondrial activity, cell division and metabolism, as well as development of new technology for studying protein-protein networks, membrane protein assembly and post-transcriptional gene expression.
StatusFinished
Effective start/end date7/01/1331/12/15

Funding

  • Australian Research Council (ARC): AUD335,000.00