A Proof of Concept, Phase IIa, Open Label Study to Evaluate the Safety of Afamelanotide in Patients with acute Arterial Ischaemic Stroke (AIS) due to Distal [M2 segment and beyond] Arterial Large Vessel Occlusion (LVO) or Perforator Occlusion and who are ineligible for Intravenous Thrombolysis (IVT) or Endovascular Thrombectomy (EVT).