Project Description
In animals growth is controlled by signalling pathways that are activated by secreted peptide hormones. The
fruitfly Drosophila provides a powerful genetic system for studying how these pathways are controlled. We have
identified a new regulator of growth in Drosophila, the Membrane Attack Complex/Perforin-like (MACPF) protein
Torso-like. This project aims to unravel how Torso-like functions to regulate growth, thus throwing light on the role
this protein family may play in all animals. Our findings will provide key insights into the modification of growth
factor activity, which is often dysregulated in human cancers and growth disorders, and may enable the design of
new strategies for interfering with insect development for pest control.
fruitfly Drosophila provides a powerful genetic system for studying how these pathways are controlled. We have
identified a new regulator of growth in Drosophila, the Membrane Attack Complex/Perforin-like (MACPF) protein
Torso-like. This project aims to unravel how Torso-like functions to regulate growth, thus throwing light on the role
this protein family may play in all animals. Our findings will provide key insights into the modification of growth
factor activity, which is often dysregulated in human cancers and growth disorders, and may enable the design of
new strategies for interfering with insect development for pest control.
| Status | Active |
|---|---|
| Effective start/end date | 1/01/16 → 30/08/20 |
Funding
- Australian Research Council (ARC): AUD379,400.00
- Monash University