A new player in microglial activation driving inflammation and pathology in traumatic brain injury [TBI].

Project: Research

Project Description

Aim: To determine whether SHIP-1 deficiency in mice leads to hyperactive microglia and exacerbated inflammatory responses in the normal brain as well as following experimental traumatic brain injury (TBI), thereby identifying SHIP-1 as a critical regulator of these brain-resident immune cells, providing scope for SHIP-1 pathway modulation for therapy.

The grant offers $5000 for use to support pilot data towards a larger grant application and to support mid-career researchers.
Short titleMicroglia in TBI
StatusActive
Effective start/end date25/03/1924/03/20

Keywords

  • traumatic brain injury (TBI)
  • microglia
  • neuropathology
  • immune response