A global approach to structure, assembly and function of yeast mitochondrial ATP synthase

Project: Research

Project Description

ATP synthase is responsible for the synthesis of the ubiquitous energy substance ATP in living cells. This multisubunit enzyme complex is a molecular rotatory motor whose mechanism relies on functional dynamic interactions of the component protein subunits of the complex. Using a combination of powerful and sophisticated molecular biology techniques the functional and dynamic contacts made by subunits within the complex, or between ATP synthase and other enzyme complex involved in energy production (including other ATP synthase complexes) will be investigated. New and significant insights into one of the most fundamental and challenging enzymes of life will be obtained.
StatusFinished
Effective start/end date1/01/0231/12/04

Funding

  • Australian Research Council (ARC): AUD375,000.00