A centre for structural cryo-electron microscopy

  • Whisstock, James (Primary Chief Investigator (PCI))
  • Dougan, David (Chief Investigator (CI))
  • Hoogenraad, Nicholas (Chief Investigator (CI))
  • Kvansakul, Marc (Chief Investigator (CI))
  • Lithgow, Trevor (Chief Investigator (CI))
  • Puthalakath, Hamsa (Chief Investigator (CI))
  • Ramm, Georg (Chief Investigator (CI))
  • Rood, Julian (Chief Investigator (CI))
  • Stojanovski, Diana (Chief Investigator (CI))
  • Colman, Peter (Partner Investigator (PI))
  • Czabotar, Peter Edward (Partner Investigator (PI))
  • Lawrence, Michael S. (Partner Investigator (PI))

Project: Research

Project Description

We seek to establish a centre for structural cryo-electron microscopy (Cryo-EM). Cryo-EM is a technique that
can be used to reveal the shape of large, complex, biological molecules. Seminal discoveries made using
EM include the structure of whole viruses, the initial reconstruction of the entire ribosomal machinery and the
structure of chaperones that guide proper protein folding. When combined with complementary techniques
such as X-ray crystallography and Nuclear Magnetic Resonance, cryo-EM gives detailed insight into how
large protein complexes assemble and function. Understanding such events in exquisite detail drives our
ability to design and develop therapeutics to correct aberrant protein function in disease.
StatusFinished
Effective start/end date1/01/12 → 31/12/13
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