Project Description
We seek to establish a centre for structural cryo-electron microscopy (Cryo-EM). Cryo-EM is a technique that
can be used to reveal the shape of large, complex, biological molecules. Seminal discoveries made using
EM include the structure of whole viruses, the initial reconstruction of the entire ribosomal machinery and the
structure of chaperones that guide proper protein folding. When combined with complementary techniques
such as X-ray crystallography and Nuclear Magnetic Resonance, cryo-EM gives detailed insight into how
large protein complexes assemble and function. Understanding such events in exquisite detail drives our
ability to design and develop therapeutics to correct aberrant protein function in disease.
can be used to reveal the shape of large, complex, biological molecules. Seminal discoveries made using
EM include the structure of whole viruses, the initial reconstruction of the entire ribosomal machinery and the
structure of chaperones that guide proper protein folding. When combined with complementary techniques
such as X-ray crystallography and Nuclear Magnetic Resonance, cryo-EM gives detailed insight into how
large protein complexes assemble and function. Understanding such events in exquisite detail drives our
ability to design and develop therapeutics to correct aberrant protein function in disease.
| Status | Finished |
|---|---|
| Effective start/end date | 1/01/12 → 31/12/13 |