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• A Multicenter, Open-label, Phase 1 Trial of bacTRL-IL-12 in Adult Subjects with Advanced, Treatment-Refractory Solid Tumors

  Pook, D.

  26/09/19 → 25/09/24

  Project: Research

• A Multicenter, Open-label, Phase I/II Dose Escalation and Expansion Study to Evaluate the Safety, Tolerability, Efficacy and Pharmacokinetics of YH003 in combination with Toripalimab (anti-PD-1mAb) in Subjects with Advanced Solid Tumors.

  Markman, B. & Hawkins, C.

  20/10/20 → 31/12/22

  Project: Research

• A Multicenter, Open-Label, Randomized Phase III Study to Evaluate the Efficacy and Safety of the Combination of Belantamab Mafodotin, Bortezomib, and Dexamethasone (B-Vd) Compared with the Combination of Daratumumab, Bortezomib and Dexamethasone (D-Vd) in Participants with Relapsed/Refractory Multiple Myeloma – DREAMM 7.

  Spencer, A. & Kennedy, N.

  22/09/20 → 31/12/25

  Project: Research

• A Multicenter, Open-label Extension Study to Evaluate the Safety, Pharmacodynamics, and Clinical Effects of WVE-120101 in Patients with Huntington's Disease.

  O'Brien, T. & Burn, K.

  1/09/20 → 30/04/23

  Project: Research

• A Multicenter, Open-label Extension Study to Evaluate the Safety, Pharmacodynamics, and Clinical Effects of WVE-120101 in Patients with Huntington’s Disease

  Kempster, P.

  17/04/20 → 16/04/25

  Project: Research

• A Multicenter, Open-label Extension Study to Evaluate the Safety, Pharmacodynamics, and Clinical Effects of WVE-120102 in Patients with Huntington's Disease.

  O'Brien, T. & Burn, K.

  1/09/20 → 30/04/23

  Project: Research

• A Multicenter, Open-label Extension Study to Evaluate the Safety, Pharmacodynamics, and Clinical Effects of WVE-120102 in Patients with Huntington’s disease

  Kempster, P.

  11/02/20 → 10/02/25

  Project: Research

• A Multicenter, Open-label Phase 1b Study of the Combination of Binimetinib and Encorafenib in Adolescent Patients with Unresectable or Metastatic BRAFV600-mutant Melanoma

  Wood, P.

  26/02/20 → 25/02/25

  Project: Research

• A Multicenter, Open-label Phase 2 Study of Lenvatinib Plus Pembrolizumab in Previously Treated Subjects with Selected Solid Tumors (LEAP-005).

  Gill, S. & Cross, N.

  22/03/19 → 31/12/24

  Project: Research

• A Multicenter, Phase 3, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy and Safety of Bimekizumab in the Treatment of Subjects with Active Psoriatic Arthritis

  Roberts, L.

  21/11/19 → 20/11/24

  Project: Research

• RESOLUTE: A Multicenter, Randomized, Double-blind, Chronic-dosing, Parallel-group, Placebo-controlled Phase 3 Study to Evaluate the Efficacy and Safety of Benralizumab 100 mg in Patients with Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD) with a History of Frequent COPD Exacerbations and Elevated Peripheral Blood Eosinophils

  Dabscheck, E. & Hazard, A.

  30/06/20 → 31/12/23

  Project: Research

• A multi-center, randomized, double-blind, parallel-group, placebo-controlled study of mepolizumab 100 mg SC as add-on treatment in participants with COPD experiencing frequent exacerbations and characterized by eosinophil levels (Study 208657)

  Bardin, P.

  9/01/20 → 8/01/25

  Project: Research

• A multicenter, randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of padsevonil as adjunctive treatment of focal-onset seizures in adult subjects with drug-resistant epilepsy.

  O'Brien, T., Kwan, P., D'Souza, W. J., Berkovic, S. F., Carney, P., Nikpour, A., Reutens, D. C. & Frasca, J.

  10/10/19 → 31/12/21

  Project: Research

• A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 1b/2a Study of WVE-120101 Administered Intrathecally in Patients with Huntington's Disease.

  O'Brien, T., Bertram, K. & Burn, K.

  18/09/19 → 31/10/21

  Project: Research

• A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 1b/2a Study of WVE-120102 Administered Intrathecally in Patients with Huntington's Disease.

  O'Brien, T., Bertram, K. & Burn, K.

  18/09/19 → 31/10/21

  Project: Research

• A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 1b/2a Study of WVE-120102 Administered Intrathecally in Patients with Huntington’s Disease

  Kempster, P.

  3/06/19 → 2/06/24

  Project: Research

• A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study of the Bruton's Tyrosine Kinase(BTK) Inhibitor, Ibrutinib, in Combination with Rituximab versus Placebo in Combination with Rituximab in Treatment Naive Subjects with Follicular Lymphoma

  Opat, S.

  30/04/19 → 29/04/24

  Project: Research

• A Multicenter, Randomized, Open-label, 3-Arm Phase 3 Study of Encorafenib + Cetuximab Plus or Minus Binimetinib vs. Irinotecan/Cetuximab or Infusional 5-Fluorouracil (5-FU)/Folinic Acid (FA)/Irinotecan (FOLFIRI)/Cetuximab with a Safety Lead-in of Encorafenib + Binimetinib + Cetuximab in Patients with BRAF V600E-mutant Metastatic Colorectal Cancer

  Strickland, A.

  11/01/19 → 10/01/24

  Project: Research

• A Multicenter, Randomized, Open-Label, Phase 3 Trial Comparing LOXO-292 to Platinum-Based and Pemetrexed Therapy with or without Pembrolizumab as Initial Treatment of Advanced or Metastatic RET Fusion-Positive Non-Small Cell Lung Cancer

  Parakh, S. & Alamgeer, M.

  27/11/19 → 26/11/24

  Project: Research

• A Multicenter, Randomized, Open-label, Phase 3 Trial Comparing Selpercatinib to Physicians Choice of Cabozantinib or Vandetanib in Patients with Progressive, Advanced, Kinase Inhibitor Naive, RET-Mutant Medullary Thyroid Cancer (LIBRETTO-531).

  Topliss, D. & Davids, F.

  11/08/20 → 3/03/23

  Project: Research

• A multicenter, single arm, study of daratumumab-lenalidomide-dexamethasone (DRd) for newly diagnosed transplant eligible multiple myeloma patients who fail bortezomib-based induction therapy.

  Spencer, A. & Kennedy, N.

  13/02/19 → 29/02/24

  Project: Research

• A multicentre, double-blind, randomised, placebo-controlled study to evaluate the safety and efficacy of MK-0767 added to Metformin in patients with inadequately controlled Type 2 Diabetes Mellitus.

  Salem, H.

  2/01/03 → 31/12/03

  Project: Research

• A multicentre, double-blind, randomised, placebo-controlled study to evaluate the safety and efficacy of MK-0767 added to Sulfonylurea in patients with inadequately controlled Type 2 Diabetes Mellitus

  Salem, H.

  2/01/03 → 31/12/03

  Project: Research

• A Multicentre, Double-Blind, Randomized, Placebo Controlled, Parallel group, Phase 3 Safety Extension Study to Evaluate the Safety and Tolerability of Tezepelumab in Adults and Adolescents with Severe Uncontrolled Asthma (DESTINATION)

  Gillman, A. & Hazard, A.

  2/12/19 → 1/05/22

  Project: Research

• A multicentre, International, Randomised, Double blind Alendronate-controlled study to determine the efficacy and safety of AMG 785 in the treatment of Postmenopausal Women with Osteoperosis

  Gilfillan, C.

  27/08/12 → 3/05/13

  Project: Research

• A Multicentre, Multinational, Randomised, Double-Blind Study Of Fondaparinux (Org31540/SR901074) versus placebo for the prolonged prevention of VTE in hip fracture surgery.

  Narayan, K. & Leyden, M.

  24/07/01 → 31/03/02

  Project: Research

• A Multicentre, Multinational, Randomised, Double-Blind Study Of Foundaparinux (Org31540/Sr901074) Versus Placebo For Prolonged Prevention Of Vte In Hip Fracture Surgery

  Salem, H. & Coughlin, P.

  23/07/01 → 31/03/02

  Project: Research

• A Multicentre, Multinational, Randomised, Double-Blind Study To Compare The Efficacy & Safety Of Fondaparinux Sodium (Org31540/Sr901074) With Dalteparin (Fragmin) In The Prevention Of Venous Thromboem

  Salem, H.

  Project: Research

• A Multicentre, Multinational, Randomised, Doule Blind Study To Compare The Efficacy & Safety Of Fondaparinux Sodium (Org31540/Sr90107a) With Delteparin (Fragmin) In The Prevention Of Venous Thromboemb

  Narayan, K., Leyden, M. & MacGowan, K.

  1/02/02 → 31/03/03

  Project: Research

• A Multicentre, Multinational Open Label Extension Trial In Patients With Painful Peripheral Neuropathy

  Simpson, R.

  Project: Research

• A multicentre, open-label study of CP-690, 550 in subjects with moderate to severe ulcerative colitis

  Chung, A.

  16/08/12 → 29/10/13

  Project: Research

• A multicentre, Phase II, open-label, randomized study in previously untreated patients with advanced indolent non-hodgkin's lymphoma evaluating the benefit of GA101 (RO5072759) plus chemotherapy compared with Rituximab plus chemotherapy followed by GA101 or Rituximab maintenance therapy in responders BO21223

  Opat, S.

  17/07/19 → 16/07/24

  Project: Research

• A MultiCentre, Phase III, Open-Label, Randomized Study In Relapsed/Refractory Patients With Chronic Lymphocytic Leukemia To Evaluate The Benefit Of GDC-0199 (ABT-199) Plus Rituximab Compared With Bendamustine Plus Rituximab

  Opat, S.

  19/05/20 → 18/05/25

  Project: Research

• A Multi-Centre, Prospective, Double Blinded, Randomised Controlled Trial to Prevent Chronic Post-Thoractomy Pain: Working Towards Preventing Acute and Chronic Pain After Major Breast Surgery

  Chow, T. K. F. & Goodchild, C.

  Trustee for Harold and Cora Brennen Benevolent Trust

  2/10/01 → 31/12/01

  Project: Research

• A multicentre, prospective, open label study to assess the safety and performance of the Genio™ bilateral hypoglossal nerve stimulation system for the treatment of Obstructive Sleep Apnoea in adult patients with and without complete concentric collapse of the soft palate

  Mansfield, D.

  18/10/19 → 17/10/24

  Project: Research

• A multicentre, ramdomised, open label phase 3 study comparing the efficacy and safety of once daily (O.D) ORG31540/SR90107A versus adjusted dose intravenous (I.V) unfractioned heparin (UFH) in the ini

  Salem, H.

  1/09/00 → 28/02/02

  Project: Research

• A Multicentre, Randomised, double blind, parallel group, placebo controlled study comparing the efficacy and safety of LY2439821 to Etanercept and placebo in patients with moderate to severe plaque ps

  Su, J.

  1/08/12 → 30/11/17

  Project: Research

• A multicentre, randomised, double blind, parallel group, placebo controlled variable treatment duration study evaluating the efficacy and safety of Piponimod (BAF312) in patients with secondary

  Butzkueven, H.

  18/02/13 → 29/05/14

  Project: Research

• A Multi-Centre, Randomised, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Efficacy and Safety of 6.0mg and 12.0mg bid Doses of Alvimopan for Treatment of Post-Operative LLeus

  O'Brien, P.

  1/04/03 → 31/03/04

  Project: Research

• A multicentre, randomised, double-blind, placebo-controlled dose finding phase 2 study of subcutaneously administered onercept in the treatment of patients with active Crohn's disease

  Gibson, P.

  Project: Research

• A multicentre, randomised, double-bllind, placebo- and active-controlled, phase 3 study to evaluate the efficacy and safety of TAK-875 25 mg and 50 mg compared to placebo and Sitagliptin 100mg

  Simpson, R.

  24/09/12 → 31/05/16

  Project: Research

• A multicentre, randomised, open-label study comparing the efficacy & safety of once daily (O.D) ORG31540/SR90107a versus adjusted dose intravenous (I.V) unfractioned heparin (UFH) In the initial treat

  Narayan, K., Leyden, M. & Rosengarten, A.

  1/11/01 → 30/04/02

  Project: Research

• A Multicentre, Randomized, Double-Blind, Placebo Controlled, Parallel group, Phase 3 Study to Evaluate the Efficacy and Safety of Tezepelumab in Adults and Adolescents with Severe Uncontrolled Asthma (NAVIGATOR).

  Gillman, A. & Hazard, A.

  2/12/19 → 31/12/20

  Project: Research

• A Multicentre, Randomized, Double-Blind, Placebo-Controlled, Phase 1b/2a Study of WVE-120101 Administered Intrathecally in Patients with Huntington's Disease

  Kempster, P.

  3/06/19 → 2/06/24

  Project: Research

• A Multicentre, Randomized, Double-Blind, Placebo-Controlled Phase III Study to Evaluate the Efficacy and Safety of Elafibranor in Patients with Nonalcoholic Steatohepatitis (NASH) and fibrosis

  Hodge, A.

  1/07/19 → 30/06/24

  Project: Research

• A multicentre, single arm, open-label, phase IIIb study to evaluate the safety and antigenicity of Rebif (IFN-beta-1a) in subjects with relapsing forms of multiple sclerosis

  Butzkueven, H. & Gibson, P.

  1/08/05 → 25/12/07

  Project: Research

• GEM3: A multi-centre double-blind placebo-controlled randomised trial of a combination of methotrexate and gefitinib versus methotrexate alone as a treatment for ectopic pregnancy – GEM3

  Horne, A. W., Mol, B. & Tong, S. Y. C.

  1/04/16 → 31/10/20

  Project: Research

• A Multi-centre feasibility study of online adaptive image guided radiotherapy for muscle invasive bladder cancer

  Richardson, J., Duchesne, G. M., Foroudi, F., Kron, T., Rolfo, A. & Turner, S.

  National Health and Medical Research Council (NHMRC) (Australia)

  1/01/10 → 31/12/12

  Project: Research

• A multicentre open-label non-randomised parallel group clinical trial to assess the efficacy of Fingolimod in naive patients v Fingolimod in patients previously treated with interferons or glatiramer

  Butzkueven, H.

  25/06/12 → 1/12/13

  Project: Research

• A multicentre open-label study to assess long term safety of PF-00547659 in subjects with moderate to severe ulcerative colitis (TURNADOT II)

  Chung, A.

  20/12/14 → 5/09/16

  Project: Research