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Personal profile

Research interests

To understand pathophysiology of diabetes associated injury in kidney and blood vessels in order to identify and validate new molecular targets for development of novel therapeutic agents to prevent, retard and treat diabetic complications such as diabetic nephropathy and diabetes associated vascular disease.

Keywords

  • Diabetes
  • Pathophysiology
  • Diabetic Complications
  • Diabetic Nephropathy
  • Renal Fibrosis
  • Diabetic Vascular Disease
  • Cell Division Autoantigen 1 (CDA1)
  • Transforming Growth Factor-beta (TGF-β)

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Projects 2017 2019

Research Output 1997 2018

Diabetes reduces severity of aortic aneurysms depending on the presence of cell division autoantigen 1 (CDA1)

Li, J., Huynh, P., Dai, A., Wu, T., Tu, Y., Chow, B., Kiriazis, H., Du, X. J., Bach, L. A., Wilkinson-Berka, J. L., Biros, E., Walker, P., Nataatmadja, M., West, M., Golledge, J., Allen, T. J., Cooper, M. E. & Chai, Z., 1 Apr 2018, In : Diabetes. 67, 4, p. 755-768 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Ultrasound combined with microbubbles enhances the effects of methylprednisolone in lipopolysaccharide-induced human mesangial cells

Sun, P. F., Tian, T., Chen, L. N., Fu, R. G., Xu, S. S., Ai, H., Wang, B., Zhang, J., Si, R. Y., Chai, Z., Cooper, M. E. & Ren, S. T., 1 Jun 2018, In : Journal of Pharmacology and Experimental Therapeutics. 365, 3, p. 476-484 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Diabetes and aortic aneurysm

Golledge, J., Cooper, M. E. & Chai, Z-L., 2016, In : Angiology. 67, 6, p. 510-512 3 p.

Research output: Contribution to journalEditorialOtherpeer-review

Genetic deletion of cell division autoantigen 1 retards diabetes-associated renal injury

Chai, Z-L., Dai, A., Tu, Y., Li, J., Wu, T., Wang, Y., Hale, L. J., Koentgen, F., Thomas, M. C. & Cooper, M. E., 2013, In : Journal of the American Society of Nephrology. 24, 11, p. 1782-1792 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The Modified Selenenyl Amide, M-hydroxy Ebselen, Attenuates Diabetic Nephropathy and Diabetes-Associated Atherosclerosis in ApoE/GPx1 Double Knockout Mice

Tan, S. M., Sharma, A., Yuen, D. Y. C., Stefanovic, N., Krippner, G., Mugesh, G., Chai, Z. & de Haan, J. B., 16 Jul 2013, In : PLoS ONE. 8, 7, e69193.

Research output: Contribution to journalArticleResearchpeer-review

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