Projects per year
Personal profile
Research interests
To understand pathophysiology of diabetes associated injury in kidney and blood vessels in order to identify and validate new molecular targets for development of novel therapeutic agents to prevent, retard and treat diabetic complications such as diabetic nephropathy and diabetes associated vascular disease.
Research area keywords
- Diabetes
- Pathophysiology
- Diabetic Complications
- Diabetic Nephropathy
- Renal Fibrosis
- Diabetic Vascular Disease
- Cell Division Autoantigen 1 (CDA1)
- Transforming Growth Factor-beta (TGF-β)
Network
Recent external collaboration on country level. Dive into details by clicking on the dots or
Projects
- 2 Finished
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Pharmacological inhibition of a novel target to reduce renal fibrosis
1/01/17 → 31/12/19
Project: Research
Research output
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Genetic deletion of a short fragment of glucokinase in rabbit by CRISPR/Cas9 leading to hyperglycemia and other typical features seen in MODY-2
Song, Y., Sui, T., Zhang, Y., Wang, Y., Chen, M., Deng, J., Chai, Z., Lai, L. & Li, Z., 1 Aug 2020, In : Cellular and Molecular Life Sciences. 77, 16, p. 3265-3277 13 p.Research output: Contribution to journal › Article › Research › peer-review
4 Citations (Scopus) -
New-Onset Diabetes in Covid-19
Rubino, F., Amiel, S. A., Zimmet, P., Alberti, K. G. M. M., Bornstein, S., Eckel, R. H., Mingrone, G., Boehm, B. O., Cooper, M. E., Chai, Z-L., Prato, S. D., Ji, L., Hopkins, D. L., Herman, W. H., Khunti, K., Mbanya, J. C. N. & Renard, E., 20 Aug 2020, In : The New England Journal of Medicine. 383, 8, p. 789-791 3 p.Research output: Contribution to journal › Letter › Other › peer-review
Open Access93 Citations (Scopus) -
Targeting the CDA1/CDA1BP1 axis retards renal fibrosis in experimental diabetic nephropathy
Chai, Z., Wu, T., Dai, A., Huynh, P., Koentgen, F., Krippner, G., Ren, S. & Cooper, M. E., 1 Feb 2019, In : Diabetes. 68, 2, p. 395-408 14 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile3 Citations (Scopus) -
Transforming growth factor β (TGFβ) and related molecules in chronic kidney disease (CKD)
Huynh, P. & Chai, Z., 1 Jan 2019, In : Clinical Science. 133, 2, p. 287-313 27 p.Research output: Contribution to journal › Review Article › Research › peer-review
19 Citations (Scopus) -
Diabetes reduces severity of aortic aneurysms depending on the presence of cell division autoantigen 1 (CDA1)
Li, J., Huynh, P., Dai, A., Wu, T., Tu, Y., Chow, B., Kiriazis, H., Du, X. J., Bach, L. A., Wilkinson-Berka, J. L., Biros, E., Walker, P., Nataatmadja, M., West, M., Golledge, J., Allen, T. J., Cooper, M. E. & Chai, Z., Apr 2018, In : Diabetes. 67, 4, p. 755-768 14 p.Research output: Contribution to journal › Article › Research › peer-review
7 Citations (Scopus)