Projects per year
Personal profile
Research interests
To understand pathophysiology of diabetes associated injury in kidney and blood vessels in order to identify and validate new molecular targets for development of novel therapeutic agents to prevent, retard and treat diabetic complications such as diabetic nephropathy and diabetes associated vascular disease.
Keywords
- Diabetes
- Pathophysiology
- Diabetic Complications
- Diabetic Nephropathy
- Renal Fibrosis
- Diabetic Vascular Disease
- Cell Division Autoantigen 1 (CDA1)
- Transforming Growth Factor-beta (TGF-β)
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Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2017 2019
- 1 Active
Pharmacological inhibition of a novel target to reduce renal fibrosis
1/01/17 → 31/12/19
Project: Research
Research Output 1997 2019
Targeting the CDA1/CDA1BP1 axis retards renal fibrosis in experimental diabetic nephropathy
Chai, Z., Wu, T., Dai, A., Huynh, P., Koentgen, F., Krippner, G., Ren, S. & Cooper, M. E., 1 Feb 2019, In : Diabetes. 68, 2, p. 395-408 14 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
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Diabetes reduces severity of aortic aneurysms depending on the presence of cell division autoantigen 1 (CDA1)
Li, J., Huynh, P., Dai, A., Wu, T., Tu, Y., Chow, B., Kiriazis, H., Du, X. J., Bach, L. A., Wilkinson-Berka, J. L., Biros, E., Walker, P., Nataatmadja, M., West, M., Golledge, J., Allen, T. J., Cooper, M. E. & Chai, Z., Apr 2018, In : Diabetes. 67, 4, p. 755-768 14 p.Research output: Contribution to journal › Article › Research › peer-review
Ultrasound combined with microbubbles enhances the effects of methylprednisolone in lipopolysaccharide-induced human mesangial cells
Sun, P. F., Tian, T., Chen, L. N., Fu, R. G., Xu, S. S., Ai, H., Wang, B., Zhang, J., Si, R. Y., Chai, Z., Cooper, M. E. & Ren, S. T., 1 Jun 2018, In : Journal of Pharmacology and Experimental Therapeutics. 365, 3, p. 476-484 9 p.Research output: Contribution to journal › Article › Research › peer-review
Diabetes and aortic aneurysm
Golledge, J., Cooper, M. E. & Chai, Z-L., 2016, In : Angiology. 67, 6, p. 510-512 3 p.Research output: Contribution to journal › Editorial › Other › peer-review
Genetic deletion of cell division autoantigen 1 retards diabetes-associated renal injury
Chai, Z-L., Dai, A., Tu, Y., Li, J., Wu, T., Wang, Y., Hale, L. J., Koentgen, F., Thomas, M. C. & Cooper, M. E., 2013, In : Journal of the American Society of Nephrology. 24, 11, p. 1782-1792 11 p.Research output: Contribution to journal › Article › Research › peer-review