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Neurogenesis is a fundamental process of generating new neurons, which integrate into existing circuits.
Neurogenesis is important for learning and memory, ageing and neurodegenerative disorders. Both intrinsic and extrinsic mechanisms regulate neurogenesis. miRNAs are short noncoding RNAs that regulate gene expression at the posttranscriptional level that appears to be involved in multiple steps of neurogenesis. However, it is not clear how these miRNAs are modulated during neurogenesis. This proposal broadly aims to identify promoters of miRNAs, such as mir9, that mediate pathways specifically regulated neurogenesis.



Research area keywords

  • Stem Cell Biology
  • Regenerative Medicine
  • learning disorders

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Projects 2014 2023

Research Output 2005 2019

Impaired cognitive function and altered hippocampal synaptic plasticity in mice lacking dermatan sulfotransferase Chst14/D4st1

Li, Q., Wu, X., Na, X., Ge, B., Wu, Q., Guo, X., Ntim, M., Zhang, Y., Sun, Y., Yang, J., Xiao, Z., Zhao, J. & Li, S., 11 Feb 2019, In : Frontiers in Molecular Neuroscience. 12, 10 p., 26.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
1 Citation (Scopus)

Paeoniflorin attenuates impairment of spatial learning and hippocampal long-term potentiation in mice subjected to chronic unpredictable mild stress

Liu, S. C., Hu, W-Y., Zhang, W. Y., Yang, L., Li, Y., Xiao, Z-C., Zhang, M. & He, Z-Y., Sep 2019, In : Psychopharmacology. 236, 9, p. 2823-2834 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Post-stroke gastrodin treatment ameliorates ischemic injury and increases neurogenesis and restores the Wnt/β-Catenin signaling in focal cerebral ischemia in mice

Qiu, C. W., Liu, Z. Y., Zhang, F. L., Zhang, L., Li, F., Liu, S. Y., He, J. Y. & Xiao, Z. C., 1 Jun 2019, In : Brain Research. 1712, p. 7-15 9 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Application of nanodiagnostics and nanotherapy to CNS diseases

Zhang, W., Wang, W., Yu, D. X., Xiao, Z. & He, Z., 1 Sep 2018, In : Nanomedicine. 13, 18, p. 2341-2371 31 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
4 Citations (Scopus)

APP upregulation contributes to retinal ganglion cell degeneration via JNK3

Liu, C., Zhang, C. W., Zhou, Y., Wong, W. Q., Lee, L. C., Ong, W. Y., Yoon, S. O., Hong, W., Fu, X. Y., Soong, T. W., Koo, E. H., Stanton, L. W., Lim, K. L., Xiao, Z-C. & Dawe, G. S., 1 Mar 2018, In : Cell Death and Differentiation. 25, 4, p. 661-676 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access