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Neurogenesis is a fundamental process of generating new neurons, which integrate into existing circuits.
Neurogenesis is important for learning and memory, ageing and neurodegenerative disorders. Both intrinsic and extrinsic mechanisms regulate neurogenesis. miRNAs are short noncoding RNAs that regulate gene expression at the posttranscriptional level that appears to be involved in multiple steps of neurogenesis. However, it is not clear how these miRNAs are modulated during neurogenesis. This proposal broadly aims to identify promoters of miRNAs, such as mir9, that mediate pathways specifically regulated neurogenesis.
http://www.med.monash.edu.au/anatomy/research/neurodegeneration-group.html
Keywords
- Stem Cell Biology
- Regenerative Medicine
- learning disorders
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Research Output 2005 2019
Impaired cognitive function and altered hippocampal synaptic plasticity in mice lacking dermatan sulfotransferase Chst14/D4st1
Li, Q., Wu, X., Na, X., Ge, B., Wu, Q., Guo, X., Ntim, M., Zhang, Y., Sun, Y., Yang, J., Xiao, Z., Zhao, J. & Li, S., 11 Feb 2019, In : Frontiers in Molecular Neuroscience. 12, 10 p., 26.Research output: Contribution to journal › Article › Research › peer-review
Open Access
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Paeoniflorin attenuates impairment of spatial learning and hippocampal long-term potentiation in mice subjected to chronic unpredictable mild stress
Liu, S. C., Hu, W-Y., Zhang, W. Y., Yang, L., Li, Y., Xiao, Z-C., Zhang, M. & He, Z-Y., 21 May 2019, (Accepted/In press) In : Psychopharmacology. 12 p.Research output: Contribution to journal › Article › Research › peer-review
Post-stroke gastrodin treatment ameliorates ischemic injury and increases neurogenesis and restores the Wnt/β-Catenin signaling in focal cerebral ischemia in mice
Qiu, C. W., Liu, Z. Y., Zhang, F. L., Zhang, L., Li, F., Liu, S. Y., He, J. Y. & Xiao, Z. C., 1 Jun 2019, In : Brain Research. 1712, p. 7-15 9 p.Research output: Contribution to journal › Article › Research › peer-review
Application of nanodiagnostics and nanotherapy to CNS diseases
Zhang, W., Wang, W., Yu, D. X., Xiao, Z. & He, Z., 1 Sep 2018, In : Nanomedicine. 13, 18, p. 2341-2371 31 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access
File
APP upregulation contributes to retinal ganglion cell degeneration via JNK3
Liu, C., Zhang, C. W., Zhou, Y., Wong, W. Q., Lee, L. C., Ong, W. Y., Yoon, S. O., Hong, W., Fu, X. Y., Soong, T. W., Koo, E. H., Stanton, L. W., Lim, K. L., Xiao, Z-C. & Dawe, G. S., 1 Mar 2018, In : Cell Death and Differentiation. 25, 4, p. 661-676 16 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
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