Projects per year
Personal profile
Biography
Professor Andrews received his PhD in New Zealand at the University of Otago in 2003 and undertook postdoctoral training at Yale University, New Haven, Connecticut, USA (2004-2008). He moved to Monash University in Melbourne, Australia in 2009 and established his own laboratory.
Professor Andrews is internationally recognised for his work on the neuroendocrine control of energy homeostasis and behaviour. He is the currently Deputy Head of the Metabolism, Diabetes and Obesity Program at the Monash Biomedicine Discovery Institute, the Editor-in-Chief for Endocrinology, the president of Hypothalamic Neuroscience and Neuroendocrinology Australasia (HNNA), and a council member on the International Neuroendocrine Federation.
Professor Andrews uses animal models and viral genetic techniques to study how the brain controls food intake and associated behaviours. This includes the role of homeostatic, reward, stress and motivational systems, and how they interact to influence both the need and the desire to eat. His lab is particularly interested in why and how the brain promotes the overconsumption of highly palatable energy dense foods and how this contributes to obesity. His group uses modern neuroscience techniques such as in vivo calcium imaging, optogenetics and chemogenetics to probe the physiological and behavioural function of neural circuits responding to hunger and regulating appetite. He has primarily focused on the hormone ghrelin, as a key hormonal signal of hunger, and AgRP neurons, as key hunger-sensing, neurons. He is recognised as a world leading expert in this field and his current work focuses on how these hunger-sensing systems control food intake and related behaviours such as reward, motivation, mood, memory and cognition.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Satiety
- Energy balance
- Memory
- Hunger
- Hypothalamus
- Cognition
- Feeding behaviour
- Dopamine
- Ventral Tegmental Area
- Neuroendocrinology
- Behaviour
- Feeding Experimental Device 3 (FED3)
- Anti-obesity medication
- GLP1R agonist/coagonist
- Mood
- In vivo Photometry
- Motivation
- Stress
- GHSR
- Growth hormone secretagogue receptor
- transgenic mice
- Optogenetics
- neuropeptide y
- Pro-opiomelanocortin
- Arcuate nucleus
- Diet-induced obesity
- Calorie restriction
- Reward
- Semaglutide
- Ghrelin
- Olfaction
- Appetite regulation
- Calcium Imaging
- learning
- Reinforcement learning
- Smell
Collaborations and top research areas from the last five years
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Hunger flexibly modifies hypothalamic neural circuits responding to threat.
Andrews, Z. (Primary Chief Investigator (PCI)), Dayas, C. (Chief Investigator (CI)), Manning, E. (Chief Investigator (CI)) & Graham, B. (Chief Investigator (CI))
23/05/22 → 22/05/26
Project: Research
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Top down cortical control of hypothalamic feeding circuits
Andrews, Z. (Primary Chief Investigator (PCI)), Verdejo-Garcia, A. (Associate Investigator (AI)), Foldi, C. (Associate Investigator (AI)), Li, Y. (Associate Investigator (AI)) & Kravitz, A. (Associate Investigator (AI))
1/01/22 → 31/12/25
Project: Research
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Targeting the brain and sympathetic nervous system to improve outcomes in cancer cachexia
Lockie, S. (Primary Chief Investigator (PCI)), Walton, K. (Associate Investigator (AI)), Andrews, Z. (Associate Investigator (AI)), Stark, R. (Associate Investigator (AI)), Oldfield, B. (Associate Investigator (AI)), Sloan, E. (Associate Investigator (AI)) & Gregorevic, P. (Associate Investigator (AI))
1/01/22 → 31/12/25
Project: Research
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Can psychedelics treat anorexia nervosa? Insights into the therapeutic effects of psilocybin in an animal model
Foldi, C. (Primary Chief Investigator (PCI)), Oldfield, B. (Associate Investigator (AI)), Andrews, Z. (Associate Investigator (AI)), Liknaitzky, P. (Associate Investigator (AI)), Hohwy, J. (Associate Investigator (AI)), Razi, A. (Associate Investigator (AI)) & Kaye, W. H. (Associate Investigator (AI))
1/01/22 → 31/12/26
Project: Research
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NHMRC Equipment Grant - New system to manipulate neural circuit dynamics based on Digital Mirror Device (DMD) technology
Shimaoka, D. (Primary Chief Investigator (PCI)), Cowley, M. (Chief Investigator (CI)), Hall, G. S. (Chief Investigator (CI)), Rosa, M. (Chief Investigator (CI)), Andrews, Z. (Chief Investigator (CI)), Coxon, J. (Chief Investigator (CI)), Fornito, A. (Chief Investigator (CI)), Pang, J. (Chief Investigator (CI)), Tsuchiya, N. (Chief Investigator (CI)) & Bellgrove, M. (Chief Investigator (CI))
1/11/23 → 31/12/24
Project: Research
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Acute inhibition of hunger-sensing AgRP neurons promotes context-specific learning in mice
Reed, F., Reichenbach, A., Dempsey, H., Clarke, R. E., Mequinion, M., Stark, R., Rawlinson, S., Foldi, C. J., Lockie, S. H. & Andrews, Z. B., Nov 2023, In: Molecular Metabolism. 77, 13 p., 101803.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus) -
UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals
Andrews, Z. B., Liu, Z.-W., Wallingford, N., Erion, D. M., Borok, E., Friedman, J. M., Tschop, M. H., Shanabrough, M., Cline, G., Shulman, G. I., Coppola, A., Gao, X.-B., Horvath, T. L. & Diano, S., 2008, In: Nature. 454, 7206, p. 846 - 851 6 p.Research output: Contribution to journal › Article › Research › peer-review
628 Citations (Scopus) -
Daily feeding entrains hunger-sensing neurons
Andrews, Z. B., Jan 2024, In: Nature Neuroscience. 27, 1, p. 10-12 3 p.Research output: Contribution to journal › Comment / Debate › Other › peer-review
1 Citation (Scopus) -
Identification of a Stress-Sensitive Anorexigenic Neurocircuit From Medial Prefrontal Cortex to Lateral Hypothalamus
Clarke, R. E., Voigt, K., Reichenbach, A., Stark, R., Bharania, U., Dempsey, H., Lockie, S. H., Mequinion, M., Lemus, M., Wei, B., Reed, F., Rawlinson, S., Nunez-Iglesias, J., Foldi, C. J., Kravitz, A. V., Verdejo-Garcia, A. & Andrews, Z. B., 15 Feb 2023, In: Biological Psychiatry. 93, 4, p. 309-321 13 p.Research output: Contribution to journal › Article › Research › peer-review
12 Citations (Scopus) -
Diet-induced obesity causes ghrelin resistance in arcuate NPY/AgRP neurons
Briggs, D. I., Enriori, P. J., Lemus, M. B., Cowley, M. A. & Andrews, Z. B., 2010, In: Endocrinology. 151, 10, p. 4745 - 4755 11 p.Research output: Contribution to journal › Article › Research › peer-review
274 Citations (Scopus)
Prizes
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2016 Editorial Board Best Reviewers awarded at ENDO 2017 in Orlando
Andrews, Z. (Recipient), 2017
Prize: National/international honour
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Endocrine Society of Australia Mid-Career research award
Andrews, Z. (Recipient), 2013
Prize: Prize (including medals and awards)
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International Servier Award at the International Congress of Neuroendocrinology
Andrews, Z. (Recipient), 2010
Prize: Prize (including medals and awards)
Activities
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Hypothalamic Neuroscience and Neuroendocrinology Australasia 2019
Andrews, Z. (Member of programme committee)
2019Activity: Participating in or organising an event types › Contribution to conference
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La Trobe University, Victoria, Australia
Andrews, Z. (Invited speaker)
2019Activity: Participating in or organising an event types › Contribution to workshop, seminar, course
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Annual Meeting of the International Behavioral Neuroscience Society 2019
Andrews, Z. (Session chair)
2019Activity: Participating in or organising an event types › Contribution to conference
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International Congress on Obesity and Metabolic Syndrome & Asia-Oceania Conference on Obesity; Korean Society for the Study of Obesity
Andrews, Z. (Invited speaker)
2019Activity: Participating in or organising an event types › Contribution to conference
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Annual Conference of Chinese Society for Neurobiological Control of Metabolism 2019
Andrews, Z. (Invited speaker)
2019Activity: Participating in or organising an event types › Contribution to conference
Press/Media
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Your body wants to be fat. Science wants to change its mind
14/02/18
6 items of Media coverage
Press/Media: Expert Comment
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CSIRO profiting from weight loss pill with no scientific backing
20/03/19
1 Media contribution
Press/Media: Expert Comment
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Brain study shows you like hot chips even if you believe you don’t
14/06/18
8 Media contributions
Press/Media: Expert Comment
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Sugar could rot your memory. So, how long does it take to reverse?
5/05/18
2 Media contributions
Press/Media: Expert Comment