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    3800 Clayton

    Australia

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20012023
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Personal profile

Biography

My laboratory studies how food, and the lack or food, affects the brain and behaviour. We are primarily interested in understanding the neural circuits that sense hunger or hypoglycemia and influence brain function, including energy homeostasis, glucose homeostasis, mental health and neurodegeneration.

It is becoming increasingly clear that a state of hunger elicits numerous effects on the brain, not just those related to food intake. We are interested in how these metabolic neural circuits detect hunger and hypoglycemia and regulate stress and motivation circuits and link states of hunger with mood and motivation. We believe that the complex interplay between such connected circuits may underlie co-morbidities of mental illness with metabolic dysfunction in disease such as anorexia and bulimia nervosa, obesity, Prader-Willi syndrome, binge-eating and food addictions.

In addition, the inability of the brain to appropriately sense hypoglycemia can lead to coma or death, which is a consistent concern for type-1 diabetic patients and their carers. We focus on the hormone ghrelin as a key hormonal signal of hunger to the brain and our research over a number of years shows that ghrelin relates blood glucose and many non-food associated behaviours such as anxiety and neuroprotection, 

Keywords

  • AMPK
  • CPT1
  • CRAT
  • Ghrelin
  • energy balance
  • mitochondria
  • fat metabolism
  • hypothalamus
  • Neurodegeneration
  • Parkinson's Disease
  • Dopamine
  • Ventral Tegmental Area
  • Neuroendocrinology
  • des-acyl ghrelin
  • goat
  • acyl ghrelin
  • insulin sensitivity
  • glucose
  • insulin
  • motivation
  • ghrelin receptor
  • GHSR
  • Growth hormone secretagogue receptor
  • transgenic mice
  • neuronal metabolism
  • neuropeptide y
  • pro-opiomelanocortin
  • arcuate nucleus
  • diet-induced obesity
  • calorie restriction
  • reward

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2009 2023

Research Output 2001 2019

UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals

Andrews, Z. B., Liu, Z-W., Wallingford, N., Erion, D. M., Borok, E., Friedman, J. M., Tschop, M. H., Shanabrough, M., Cline, G., Shulman, G. I., Coppola, A., Gao, X-B., Horvath, T. L. & Diano, S., 2008, In : Nature. 454, 7206, p. 846 - 851 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Diet-induced obesity causes ghrelin resistance in arcuate NPY/AgRP neurons

Briggs, D. I., Enriori, P. J., Lemus, M. B., Cowley, M. A. & Andrews, Z. B., 2010, In : Endocrinology. 151, 10, p. 4745 - 4755 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Ghrelin regulates the hypothalamic-pituitary-adrenal axis and restricts anxiety after acute stress

Spencer, S. J., Xu, L., Clarke, M. A., Lemus, M. B., Reichenbach, A., Geenen, B., Kozicz, T. & Andrews, Z. B., 2012, In : Biological Psychiatry. 72, 6, p. 457 - 465 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Ghrelin-AMPK signaling mediates the neuroprotective effects of calorie restriction in Parkinson's Disease

Bayliss, J. A., Lemus, M. B., Stark, R., Santos, V. V., Thompson, A., Rees, D. J., Galic, S., Elsworth, J. D., Kemp, B. E., Davies, J. S. & Andrews, Z. B., 9 Mar 2016, In : Journal of Neuroscience. 36, 10, p. 3049-3063 15 p.

Research output: Contribution to journalArticleResearchpeer-review

AgRP Neurons Require Carnitine Acetyltransferase to Regulate Metabolic Flexibility and Peripheral Nutrient Partitioning

Reichenbach, A., Stark, R., Mequinion, M., Denis, R. R. G., Goularte, J. F., Clarke, R. E., Lockie, S. H., Lemus, M. B., Kowalski, G. M., Bruce, C. R., Huang, C., Schittenhelm, R. B., Mynatt, R. L., Oldfield, B. J., Watt, M. J., Luquet, S. & Andrews, Z. B., 13 Feb 2018, In : Cell Reports. 22, 7, p. 1745-1759 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Activities 2004 2018

The Ghrelin Symposium

Zane Andrews (Organiser)
13 Jul 201814 Jul 2018

Activity: Participating in or organising an event typesContribution to conference

Metabolic Diseases: Breakthrough discoveries in diabetes and obesity 2018

Zane Andrews (Member of programme committee)
17 Oct 201818 Oct 2018

Activity: Participating in or organising an event typesContribution to conference

Australia and New Zealand Obesity Society Annual Meeting

Zane Andrews (Organiser)
16 Oct 201818 Oct 2018

Activity: Participating in or organising an event typesContribution to conference

Frontiers in Neuroscience (Journal)

Zane Andrews (Editorial board member)
2017 → …

Activity: Publication peer-review and editorial work typesEditorial responsibility

Endocrinology (Journal)

Zane Andrews (Associate editor)
1 Oct 2017

Activity: Publication peer-review and editorial work typesEditorial responsibility

Press / Media

Your body wants to be fat. Science wants to change its mind

Zane Andrews

14/02/18

1 media contribution

Press/Media: Expert Comment

Are you hangry

Zane Andrews

1/10/18

1 media contribution

Press/Media: Expert Comment

Sugar could rot your memory. So, how long does it take to reverse?

Zane Andrews

5/05/18

2 media contributions

Press/Media: Expert Comment

Alarming number of Australians skip lunch break, study finds

Zane Andrews

6/04/18

1 media contribution

Press/Media: Expert Comment