Research output per year
Research output per year
Personal profile
Biography
I completed my PhD with Prof. Ashok Venkitaraman at the University of Cambridge in 2013. After a short post-doc in the same lab, I started my post-doc with Prof. Mary Herbert at Newcastle University (UK) in 2015. Since then, I have been involved in developing and fine-tuning mitochondrial donation techniques in eggs to prevent transmission of mitochondrial disease to the newborn. My primary focus has been on fine-tuning the technology, which has branched out to several exciting projects.
My areas of research include:
-developing and fine-tuning mitochondrial donation techniques in eggs
-embryonic development (from zygote to blastocyst stage)
-Mitochondrial biology in oocytes and embryos
-Meiosis I and Meiosis II
In 2023, I moved to Monash University with Prof. Mary Herbert.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Developmental biology
- Meiosis
- Chromosome segregation
- Aging
- Mitochondrial replacement therapy
- Mitophagy
- Mitochondria
- Embryology
- Assisted reproductive technology
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Feasibility and impact of haplogroup matching for mitochondrial replacement treatment
Takeda, Y., Hyslop, L., Choudhary, M., Robertson, F., Pyle, A., Wilson, I., Santibanez-Koref, M., Turnbull, D., Herbert, M. & Hudson, G., 9 Oct 2023, In: EMBO Reports. 24, 10, 13 p., e54540.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Parental genome unification is highly error-prone in mammalian embryos
Cavazza, T., Takeda, Y., Politi, A. Z., Aushev, M., Aldag, P., Baker, C., Choudhary, M., Bucevičius, J., Lukinavičius, G., Elder, K., Blayney, M., Lucas-Hahn, A., Niemann, H., Herbert, M. & Schuh, M., 27 May 2021, In: Cell. 184, 11, p. 2860-2877.e22 41 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access108 Citations (Scopus) -
Reversion after replacement of mitochondrial DNA
Hudson, G., Takeda, Y. & Herbert, M., 17 Oct 2019, In: Nature. 574, 7778, p. E8-E11 4 p.Research output: Contribution to journal › Letter › Other › peer-review
29 Citations (Scopus) -
Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease
Hyslop, L. A., Blakeley, P., Craven, L., Richardson, J., Fogarty, N. M. E., Fragouli, E., Lamb, M., Wamaitha, S. E., Prathalingam, N., Zhang, Q., O'Keefe, H., Takeda, Y., Arizzi, L., Alfarawati, S., Tuppen, H. A., Irving, L., Kalleas, D., Choudhary, M., Wells, D. & Murdoch, A. P. & 3 others, , 8 Jun 2016, In: Nature. 534, 7607, p. 383-386 4 p.Research output: Contribution to journal › Article › Research › peer-review
268 Citations (Scopus) -
Micro(mi) RNA-34a targets protein phosphatase (PP)1γ to regulate DNA damage tolerance
Takeda, Y. & Venkitaraman, A. R., 1 Jan 2015, In: Cell Cycle. 14, 24, p. 3830-3841 12 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access8 Citations (Scopus)