Personal profile

Biography

Dr. Hooi Yuan Teng graduated from University of Malaya, majoring in Bioinformatics in 2011. After few years of working as research assistant with Professor Dr. Wong Kum Thong, a neuropathologist in Department of Pathology, University of Malaya. She then pursued her doctoral degree under his supervision. Her PhD research project was to develop an animal model for Coxsackievirus A16 (CV-A16) infection that cause hand-foot-mouth disease (HFMD), and to understand the infectious pathology and pathogenesis studies of CV-A16. She graduated in 2020 and currently work as a postdoctoral research fellow under Dr. Vinod RMT Balasubramaniam in the laboratory of the Infection and Immunity Cluster, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia. She has experience in animal works specializing in histopathological techniques (immunohistochemistry, in situ hybridization and etc.) and virus handling (virus culture, viral titration, PCR, qRT-PCR and etc.). In the past years, she had published several peer-reviewed journal articles, including 1 from the list of Tier 1 journals (Laboratory Investigation). She had also presented in international conferences and awarded with “Best Poster Prize” in one of the conferences (Hand, Foot and Mouth Disease International Conference 2016, Biopolis, Singapore).

 

Research interests

Summary

Enteroviruses are associated with several human and mammalian diseases. Both Coxsackievirus A16 (CV-A16) and Enterovirus A71 (EV-A71) from Enterovirus A species could cause hand-foot-mouth disease (HFMD) in human, which usually presents as a mild febrile exanthematous disease with vesicles/rashes on the palmar and plantar skin, and ulcers on the buccal mucosa and tongue. In contrast to EV-A71 encephalomyelitis, little is known about the central nervous system pathology in CV-A16 infection because to date there is no human autopsy study available on this important CV-A16 complication. In Dr. Hooi’s previous research project, she had developed CV-A16 animal models for pathogenesis and infectious disease pathology studies. The findings not only confirmed CV-A16 neurotropism, and suggested skeletal muscle and brown adipose tissue as important viral replication sites. The kinetic studies suggested neuroinvasion is possibly via retrograde axonal transport in peripheral motor nerves.

 

Some of Dr. Hooi’s previous work include:

  • Development of specific CV-A16 and EV-A71 DNA probes for in situ hybridization (ISH) in infected formalin-fixed paraffin embedded tissues.
  • Comparison of infectious disease pathology of CV-A16 and EV-A71 in mouse model.
  • Development of an orally-infected CV-A16 HFMD hamster model for the study of viral distribution and tissue tropism, viral replication kinetics, viral shedding and transmission among host animals.
  • Phenotypic and genotypic characterization of mouse adapted CV-A16 strains.

 

Currently, she is working on another species of enterovirus, EV-D68 which usually causes respiratory illness that resembles those of a cold, primarily in children. The infection ocassionally  associated with more severe clinical manifestations such as acute flaccid myelitis, aseptic meningitis and brainstem encephalitis. Research on EV-D68 has mainly focused on its epidemiology, the virologic characteristics and pathogenesis remain largely unknown and under investigated. In this project, Dr. Hooi will be involving in the development of EV-D68 animal model and histopathological experiments.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

Pathology (Infectious Disease), Doctor of Philosophy, Pathogenetic studies and molecular characterization of Coxsackievirus A16 infection using animal models and in vitro assays., Universiti Malaya (University of Malaya)

22 Apr 20161 Oct 2020

Award Date: 1 Oct 2020

Bioinformatics, Bachelor of Science (Hons.), Phylogenetic analysis of snappers (Familiy: Lutjanidae) in Peninsular Malaysia based on D-Loop sequences, Universiti Malaya (University of Malaya)

29 Jun 20088 Oct 2011

Award Date: 8 Oct 2011

Research area keywords

  • Virology
  • Infectious disease
  • Pathogenesis
  • Animal model
  • Histopathology

Collaborations and top research areas from the last five years

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