19932018

Research output per year

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Research Output

2018

Compression force sensing regulates integrin αiIbβ3 adhesive function on diabetic platelets

Ju, L., McFadyen, J. D., Al-Daher, S., Alwis, I., Chen, Y., Tønnesen, L. L., Maiocchi, S., Coulter, B., Calkin, A. C., Felner, E. I., Cohen, N., Yuan, Y., Schoenwaelder, S. M., Cooper, M. E., Zhu, C. & Jackson, S. P., 1 Dec 2018, In : Nature Communications. 9, 1, 16 p., 1087.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
12 Citations (Scopus)
2017

Corrigendum: 14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function

Schoenwaelder, S. M., Darbousset, R., Cranmer, S. L., Ramshaw, H. S., Orive, S. L., Sturgeon, S., Yuan, Y., Yao, Y., Krycer, J. R., Woodcock, J., Maclean, J., Pitson, S., Zheng, Z., Henstridge, D. C., van der Wal, D., Gardiner, E. E., Berndt, M. C., Andrews, R. K., James, D. E., Lopez, A. F. & 1 others, Jackson, S. P., 30 Aug 2017, In : Nature Communications. 8, 2 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Open Access
File
1 Citation (Scopus)

Development of a novel strategy to target CD39 antithrombotic activity to the endothelial-platelet microenvironment in kidney ischemia–reperfusion injury

Sashindranath, M., Dwyer, K. M., Dezfouli, S., Selan, C., Crikis, S., Lu, B., Yuan, Y., Hickey, M. J., Peter, K., Robson, S. C., Cowan, P. J. & Nandurkar, H. H., Jun 2017, In : Purinergic Signalling. 13, 2, p. 259-265 7 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Neutrophil macroaggregates promote widespread pulmonary thrombosis after gut ischemia

Yuan, Y., Alwis, I., Wu, M. C. L., Kaplan, Z., Ashworth, K., Bark, D., Pham, A., McFadyen, J., Schoenwaelder, S. M., Josefsson, E. C., Kile, B. T. & Jackson, S. P., 27 Sep 2017, In : Science Translational Medicine. 9, 409, 14 p., eaam5861.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)
2016

14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function

Schoenwaelder, S. M., Darbousset, R., Cranmer, S. L., Ramshaw, H. S., Orive, S. L., Sturgeon, S., Yuan, Y., Yao, Y., Krycer, J. R., Woodcock, J. M., Maclean, J., Pitson, S., Zheng, Z., Henstridge, D. C., Van Der Wal, D., Gardiner, E. E., Berndt, M. C., Andrews, R. K., James, D. E., Lopez, A. F. & 1 others, Jackson, S. P., 27 Sep 2016, In : Nature Communications. 7, 17 p., 12862.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
21 Citations (Scopus)
2015

Thrombin-dependent intravascular leukocyte trafficking regulated by fibrin and the platelet receptors GPIb and PAR4

Kaplan, Z., Zarpellon, A., Alwis, I., Yuan, Y-P., McFadyen, J. D., Ghasemzadeh, M., Schoenwaelder, S. M., Ruggeri, Z. M. & Jackson, S., 2015, In : Nature Communications. 6, (Art. No: 7835), p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
32 Citations (Scopus)
2014

Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrin aIIb{beta}3 in mice

Hughan, S. C., Spring, C. M., Schoenwaelder, S. M., Sturgeon, S. A., Alwis, I., Yuan, Y-P., McFadyen, J. D., Westein, E., Goddard, D. M., Ono, A., Yamanashi, Y., Nesbitt, W. S. & Jackson, S., 2014, In : Journal of Biological Chemistry. 289, 8, p. 5051 - 5060 10 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)
2013

The CXCR1/2 ligand NAP-2 promotes directed intravascular leukocyte migration through platelet thrombi

Ghasemzadeh, M., Kaplan, Z., Alwis, I., Schoenwaelder, S. M., Ashworth, K. J., Westein, E., Hosseini, E., Salem, H. H., Slattery, R. M., McColl, S. R., Hickey, M. J., Ruggeri, Z. M., Yuan, Y-P. & Jackson, S., 2013, In : Blood. 121, 22, p. 4555 - 4566 12 p.

Research output: Contribution to journalArticleResearchpeer-review

75 Citations (Scopus)
2012

A live cell micro-imaging technique to examine platelet calcium signaling dynamics under blood flow

Nesbitt, W. S., Harper, I. S., Schoenwaelder, S. M., Yuan, Y. & Jackson, S. P., 2012, In : Methods in Molecular Biology. 788, p. 73 - 89 17 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)
2011

Evidence of platelet activation at medically used hypothermia and mechanistic data indicating ADP as a key mediator and therapeutic target

Straub, A., Krajewski, S., Hohmann, J. D., Westein, E., Jia, F., Bassler, N., Selan, C., Kurz, J., Wendel, H., Dezfouli, S., Yuan, Y-P., Nandurkar, H., Jackson, S., Hickey, M. & Peter, K., 2011, In : Arteriosclerosis, Thrombosis and Vascular Biology. 31, 7, p. 1607 - 1616 10 p.

Research output: Contribution to journalArticleResearchpeer-review

52 Citations (Scopus)
2009

Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function

Schoenwaelder, S. M., Yuan, Y-P., Josefsson, E. C., White, M. J., Yao, Y., Mason, K. D., O'Reilly, L. A., Henley, K. J., Ono, A., Hsiao, S. T-F., Willcox, A. E. H., Roberts, A. W., Huang, D. C. S., Salem, H. H., Kile, B. & Jackson, S., 2009, In : Blood. 114, 3, p. 663 - 666 4 p.

Research output: Contribution to journalArticleResearchpeer-review

188 Citations (Scopus)
2007

A mechanistic model for paradoxical platelet activation by ligand-mimetic alphaIIbbeta3 (GPIIb/IIIa) antagonists

Bassler, N., Loeffler, C., Mangin, P., Yuan, Y-P., Schwarz, M., Hagemeyer, C. E., Eisenhardt, S. U., Ahrens, I., Bode, C., Jackson, S. & Peter, K., 2007, In : Arteriosclerosis, Thrombosis and Vascular Biology. 27, 3, p. 9 - 15 7 p.

Research output: Contribution to journalArticleResearchpeer-review

63 Citations (Scopus)

Are Erk, Btk, and PECAM-1 major players in GPIb signaling? The challenge of unraveling signaling events downstream of platelet GPIb

Jackson, S., Cranmer, S. L., Mangin, P. & Yuan, Y-P., 2007, In : Blood. 109, 2, p. 846 - 847 2 p.

Research output: Contribution to journalLetterOther

5 Citations (Scopus)
2006

"Pulling strings": Shear, platelets, and microparticles

Jackson, S., Mangin, P. & Yuan, Y-P., 2006, In : Blood. 107, 9, p. 3418 - 3419 2 p.

Research output: Contribution to journalArticleOther

1 Citation (Scopus)

Thrombin overcomes the thrombosis defect associated with platelet GPVI/FcRgamma deficiency

Mangin, P., Yap, C. L. S., Nonne, C., Sturgeon, S. A., Goncalves, I., Yuan, Y., Schoenwaelder, S. M., Wright, C. E., Lanza, F. & Jackson, S., 2006, In : Blood. 107, 11, p. 4346 - 4353 8 p.

Research output: Contribution to journalArticleResearchpeer-review

112 Citations (Scopus)
2005

Importance of temporal flow gradients and integrin alphaIIbbeta3 mechanotransduction for shear activation of platelets

Goncalves, I., Nesbitt, W. S., Yuan, Y. & Jackson, S. P., 2005, In : Journal of Biological Chemistry. 280, 15, p. 15430 - 15437 8 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

PI 3-kinase p110beta: A new target for antithrombotic therapy

Jackson, S. P., Schoenwaelder, S. M., Goncalves, I., Nesbitt, W. S., Yap, C. L-S., Wright, C. E., Kenche, V. B., Anderson, K. E., Dopheide, S. M., Yuan, Y., Sturgeon, S. A., Prabaharan, H., Thompson, P. E., Smith, G. D., Shepherd, P. R., Daniele, N., Kulkarni, S., Abbott, B., Saylik, D., Jones, C. & 6 others, Lu, L., Giuliano, S., Hughan, S. C., Angus, J. A., Robertson, A. D. & Salem, H. H., 2005, In : Nature Medicine. 11, 5, p. 507 - 514 8 p.

Research output: Contribution to journalArticleResearchpeer-review

462 Citations (Scopus)
2004

SHIP1 and Lyn kinase negatively regulate integrin IIb3 signaling in platelets

Maxwell, M. J., Yuan, Y., Anderson, K. E., Hibbs, M. L., Salem, H. H. & Jackson, S. P., 2004, In : Journal of Biological Chemistry. 279, 31, p. 32196 - 32204 9 p.

Research output: Contribution to journalArticleResearchpeer-review

SHIP1 and Lyn kinase negatively regulate integrin α IIbβ3 signaling in platelets

Maxwell, M. J., Yuan, Y., Anderson, K. E., Hibbs, M. L., Salem, H. H. & Jackson, S. P., 30 Jul 2004, In : Journal of Biological Chemistry. 279, 31, p. 32196-32204 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
67 Citations (Scopus)
2003

Integrin IIb3-dependent calcium signals regulate platelet-fribrinogen interactions under flow

Goncalves, I., Hughan, S. C., Schoenwaelder, S. M., Yap, C. L. S., Yuan, Y. & Jackson, S. P., 2003, In : Journal of Biological Chemistry. 278, 37, p. 34812 - 34822 11 p.

Research output: Contribution to journalArticleResearchpeer-review

71 Citations (Scopus)

Signaling role for phospholipase Cg 2 in platelet glycoprotein Iba calcium flux and cytoskeletal reorganization. Involvement of a pathway distinct from FcRg chain and FcgRIIA

Mangin, P., Yuan, Y., Goncalves, I., Eckly, A., Freund, M., Cazenave, J-P., Gachet, C., Jackson, S. P. & Lanza, F., 2003, In : Journal of Biological Chemistry. 278, 35, p. 32880 - 32891 12 p.

Research output: Contribution to journalArticleResearchpeer-review

88 Citations (Scopus)
2001

Activation of protease-activated receptors by gingipains from Porphyromonas gingivalis leads to platelet aggregation: A new trait in microbial pathogenicity

Lourbakos, A., Yuan, Y. P., Jenkins, A. L., Travis, J., Andrade-Gordon, P., Santulli, R., Potempa, J. & Pike, R. N., 15 Jun 2001, In : Blood. 97, 12, p. 3790-3797 8 p.

Research output: Contribution to journalArticleResearchpeer-review

154 Citations (Scopus)

Activation of protease-activated receptors by gingipains from porphyromonas gingivalis leads to platelet aggregation: a new trait in micobial pathogenicity

Lourbakos, A., Yuan, Y., Jenkins, A. L., Travis, J., Andrade-Gordon, P., Santulli, R., Potempa, J. & Pike, R. N., 2001, In : Blood. 97, 12, p. 3790 - 3797 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2000

Calpain regulation of integrin alphaIIbbeta3 signaling in human platelets

Schoenwaelder, S. M., Yuan, Y. & Jackson, S. P., 2000, In : Platelets. p. 189 - 198 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Cytoskeletal regulation of the platelet glycoprotein Ib/V/IX-von Willebrand factor interaction

Mistry, N., Cranmer, S. L., Yuan, Y., Mangin, P., Dopheide, S. M., Harper, I. S., Giuliano, S., Dunstan, D. E., Lanza, F., Salem, H. H. H. & Jackson, S. P., 2000, In : Blood. p. 3480 - 3489 10 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)

Platelets and the injured vessel wall-- "rolling into action": focus on glycoprotein Ib/V/IX and the platelet cytoskeleton.

Jackson, S., Mistry, N. & Yuan, Y-P., 2000, In : Trends in Cardiovascular Medicine. 10, p. 192 - 197 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Synergistic adhesive interactions and signaling mechanisms operating between platelet glycoprotein Ib/IX and integrin αIIbβ3: Studies in human platelets and transfected Chinese hamster ovary cells

Yap, C. L., Hughan, S. C., Cranmer, S. L., Nesbitt, W. S., Rooney, M. M., Giuliano, S., Kulkarni, S., Dopheide, S. M., Yuan, Y., Salem, H. H. & Jackson, S. P., 29 Dec 2000, In : Journal of Biological Chemistry. 275, 52, p. 41377-41388 12 p.

Research output: Contribution to journalArticleResearchpeer-review

96 Citations (Scopus)

Synergistic adhesive interactions and signaling mechanisms operating between platelet glycoprotein Ib.IX and intergrin alphaIIbBeta3

Yap, C. L., Hughan, S. C., Cranmer, S. L., Nesbitt, W. S., Rooney, M. M., Giuliano, S., Kulkarni, S., Dopheide, S. M., Yuan, Y., Salem, H. H. H. & Jackson, S. P., 2000, In : Journal of Biological Chemistry. p. 41377 - 41388 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Synergistic adhesive interactions and signaling mechanisms operating between platelet gp ib/ix and integrin αiibβ3: studies in human platelets and transfected K562 and CHO cells

Jackson, S. P., Domagala, T., Hughan, S. C., Cranmer, S. L., Nesbitt, W. S., Kulkarni, S., Dopheide, S. M., Yuan, Y., Lanza, F. & Yap, C. L., 1 Dec 2000, In : Blood. 96, 11 PART I

Research output: Contribution to journalArticleResearchpeer-review

1999

The von Willebrand factor-glycoprotein Ib/V/IX interaction induces actin polymerisation and cytoskeletal reorganisation in rolling platelets and glycoprotein Ib/V/IX-transfected cells

Yuan, Y., Kulkarni, S., Ulsemer, P., Cranmer, S. L., Yap, C. L., Nesbitt, W. S., Harper, I. S., Mistry, N., Dopheide, S. M., Hughan, S. C., Williamson, D., De La Salle, C., Salem, H. H., Lanza, F. & Jackson, S. P., 1999, In : Journal of Biological Chemistry. p. 36241 - 36251 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The von Willebrand factor-glycoprotein Ib/V/IX interaction induces actin polymerization and cytoskeletal reorganization in rolling platelets and glycoprotein Ib/V/IX-transfected cells

Yuan, Y., Kulkarni, S., Ulsemer, P., Cranmer, S. L., Yap, C. L., Nesbitt, W. S., Harper, I., Mistry, N., Dopheide, S. M., Hughan, S. C., Williamson, D., De La Salle, C., Salem, H. H., Lanza, F. & Jackson, S. P., 17 Dec 1999, In : Journal of Biological Chemistry. 274, 51, p. 36241-36251 11 p.

Research output: Contribution to journalArticleResearchpeer-review

96 Citations (Scopus)
1997

Calpain Regulation of Cytoskeletal Signaling Complexes in Von Willbrand Factor-stimulated Platelets

Yuan, Y., Dopheide, S. M., Ivanidis, C., Salem, H. H. & Jackson, S. P., 1997, In : Journal of Biological Chemistry. p. 21847 - 21854 8 p.

Research output: Contribution to journalArticleResearchpeer-review

1996

Focal adhesion kinase (pp125FAK) cleavage and regulation by calpain

Cooray, P., Yuan, Y., Schoenwaelder, S. M., Mitchell, C. A., Salem, H. H. & Jackson, S. P., 15 Aug 1996, In : Biochemical Journal. 318, 1, p. 41-47 7 p.

Research output: Contribution to journalArticleResearchpeer-review

153 Citations (Scopus)
1995

An essential role for lysophosphatidylcholine in the inhibition of platelet aggregation by secretory phospholipase A2

Yuan, Y., Jackson, S. P., Newnham, H. H., Mitchell, C. A. & Salem, H. H., 1995, In : Blood. 86, 11, p. 4166-4174 9 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)
1994

Adhesion receptor activation of phosphatidylinositol 3-Kinase: Von Willebrand factor stimulates the cytoskeletal association and activation of phosphatidylinositol 3-kinase and pp60c-src in human platelets

Jackson, S. P., Schoenwaelder, S. M., Yuan, Y., Rabinowitz, I., Salem, H. H. & Mitchell, C. A., 28 Oct 1994, In : Journal of Biological Chemistry. 269, 43, p. 27093-27099 7 p.

Research output: Contribution to journalArticleResearchpeer-review

110 Citations (Scopus)

Tyrosine Kinases Regulate the Cytoskeletal Attachment of Integrin αIIbβ3 (Platelet Glycoprotein IIb/IIIa) and the Cellular Retraction of Fibrin Polymers

Schoenwaelder, S. M., Jackson, S. P., Yuan, Y., Teasdale, M. S., Salem, H. H. & Mitchell, C. A., 23 Dec 1994, In : Journal of Biological Chemistry. 269, 51, p. 32479-32487 9 p.

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)
1993

Purification and characterisation of a snake venom phospholipase A2: A potent inhibitor of platelet aggregation

Yuan, Y., Jackson, S. P., Mitchell, C. A. & Salem, H. H., 15 Jun 1993, In : Thrombosis Research. 70, 6, p. 471-481 11 p.

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)

Role of the platelet integrin glycoprotein IIb-IIIa in intracellular signalling

Jackson, S. P., Yuan, Y., Schoenwaelder, S. M. & Mitchell, C. A., 15 Jul 1993, In : Thrombosis Research. 71, 2, p. 159-168 10 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)